Inflammasomes and proteostasis novel molecular mechanisms associated with atrial fibrillation

N Li, BJJM Brundel - Circulation research, 2020 - Am Heart Assoc
… exhibits atrial ectopic activity, shortening of atrial effective refractory period, and enlarged …
In addition, in these patients, HSPB1 levels in atrial tissue correlate inversely with the amount …

[HTML][HTML] Should we abandon the term" lone atrial fibrillation"?

K Lin, JE Marine, H Calkins, S Nazarian, M Wei… - Hellenic Journal of …, 2019 - Elsevier
Atrial enlargement and fibrosis, atrial ectopy, and increased … In animals or patients who suffer
from heart failure, activity of … (OPG) correlated with matrix degradation and inflammatory cell

Heart Failure, Female Sex, and Atrial Fibrillation Are the Main Drivers of Human Atrial Cardiomyopathy: Results From the CATCH ME Consortium

J Winters, A Isaacs, S Zeemering… - Journal of the …, 2023 - Am Heart Assoc
… In the present study, the correlation between total ECM and endomysial fibrosis was …
fibrosis, but can also couple with myocytes potentially promoting reentry and ectopic activity. …

[HTML][HTML] Prediction of atrial fibrillation development and progression: current perspectives

K Vlachos, KP Letsas, P Korantzopoulos… - World journal of …, 2016 - ncbi.nlm.nih.gov
… with autonomic activity promotes ectopic firing and AF. … that clearly shows the straight
correlation between AF and OSA[… This study, also, proves the correlation between obesity and AF. …

… Cell Heterogeneity Facilitate Electrical Conduction Disturbances in a Human Induced Pluripotent Stem Cell-Based Platform: An In vitro Disease Model of Atrial …

H Nakanishi, JK Lee, K Miwa, K Masuyama… - Frontiers in …, 2019 - frontiersin.org
Ectopic foci from pulmonary veins (PVs) comprise the main trigger associated with the
initiation of atrial fibrillation (AF). An abrupt anatomical narrow-to-wide transition, modeled as in …

An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility

FM Bosada, K van Duijvenboden, AE Giovou… - Elife, 2023 - elifesciences.org
… Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary
veins. The New England Journal of Medicine 339:659–666. DOI: https://doi.org/10.1056/ …

… of low cycle length accurately reflect arrhythmogenic substrate for atrial fibrillation–implications for a new, mechanism guided therapeutic approach for atrial fibrillation

S Yoo, M Rottmann, J Ng, D Johnson, B Shanab… - bioRxiv, 2020 - biorxiv.org
… Unlike other measures, Rec% correlated closely with spatial … EMR correlates closely with
stability of rotational activity and … Spontaneous initiation of atrial fibrillation by ectopic beats

New aspects of endocrine control of atrial fibrillation and possibilities for clinical translation

M Aguilar, RA Rose, A Takawale, S Nattel… - Cardiovascular …, 2021 - academic.oup.com
… Obesity induces pro-inflammatory signalling in the atria 53 that can promote both ectopic firing
and an … EpAT volume correlates with areas of atrial fibrosis, slow conduction, electrogram …

Mechanisms of atrial fibrillation

RS Wijesurendra, B Casadei - Heart, 2019 - heart.bmj.com
… make ectopic activity more likely by producing changes in Ca 2+ handling that promote both
triggered activity … dilatation may support re-entry directly, but is also strongly correlated to the …

[HTML][HTML] Cardiomyocyte inflammasome signaling in cardiomyopathies and atrial fibrillation: mechanisms and potential therapeutic implications

G Chen, MG Chelu, D Dobrev, N Li - Frontiers in physiology, 2018 - frontiersin.org
… ryanodine receptor type-2 (RyR2), which might represent the molecular correlates of ectopic
activity as reflected by the higher incidence of premature atrial contractions. In addition, the …