… majority of the cholinergic innervation to the cortex, amygdala, … muscarinic subtypes
expressed, with M 3 and M 5 being … , thereby increasing cellular excitability across cholinergic, …

… and is expressed in pivotal brain regions (eg, the cerebral cortex and … The AChR changes
the ion-permeability of the cellular … age, which leads to the long-term increase of α7nAChR …

… However, research focused on the cellular distribution of nAChRs eventually shed some …
unchanged in the frontal and parietal cortices 55 . At the same age, APPswe mice showed no …

… to age-matched controls, there is a loss of M1 muscarinic … Using a functional rat cortical brain
slice model, we find that … mAChR protein expression in post-mortem temporal cortical tissue …

… lobe structures such as the hippocampus and entorhinal cortex [58]. In addition, separate …
mice also demonstrated greater age-dependent memory impairment, expression of amyloid …

… regions of the cortex and the brainstem ACh can promote … expression of muscarinic and
nicotinic cholinergic receptors … of cholinergic neurons in human CNS and altered in aging and …

… cortex. Current therapeutic approaches focus on restoring … The term cholinergic refers to the
receptors that respond to … scans to examine how age and AD impact muscarinic type 2 [M2] …

… neuronal physiology and the biology of Alzheimer’s disease. … course of normal aging and
especially during Alzheimer’s … synaptic cholinergic receptors abundantly expressed throughout …

… The alpha7 nicotinic acetylcholine receptor (α7-nAChR) is expressed on neurons and
has … regional volume ratio and age in striatum, temporal cortex, occipital cortex, cingulate …

… acetylcholine receptors (α4β2-AChRs) are widely expressed in … Alzheimer’s dementia and
healthy controls (adjusted for age … a priori defined cortical brain regions, such as mean cortex, …