… described to be critical for HTLV-1 transmission, tight junctions and cellular conduits. Further,
… receptor on the uninfected cell, viral particles cross the VS and enter the uninfected cell [61,…

… HTLV-1 life cycle: HTLV-1 virion interacts with the target cell surface receptors GLUT1/
HSPG/NRP-1 via the HTLV-1 … viruses enter the synaptic cleft and interact with cellular receptors. …

… , which is typically associated only with HTLV-1 infection, … proteins in HTLV-1 infectivity
and pathogenicity. p8 and p12, … early steps of infection, at the entry step, the tropism is almost …

… associated HTLV-1 viral particles fuse with the plasma membrane of target cells, or are
internalized and enter … whether this cellular model reflects the cell-to-cell transmission of HTLV-1, …

… HTLV-1 recruits many cellular and viral genes and form a protein ring in the … entry and
effective virus dissemination, and promote tissue damages involved in the HAM/TSP pathogenicity…

… cell entry to integrate into the host genome as the HTLV-1 … cellular factors involved in cell
survival and proliferation and malignancy. The HTLV-1-HBZ is a complicated regulatory factor …

… have critical roles in HTLV-1 pathogenicity, yet the underlying mechanisms of HTLV-1-driven …
HTLV-1-mediated cellular transformation and the potential therapeutic strategies to combat …

… sets, hub genes, and modules in pathogenicity were screened. … Upon virus entry and
localization in host cells, subclinical … protein to mediate cellular transformation and metastasis in …

… efforts to understand HTLV-1 pathogenicity, more research is … examined whether HTLV-1
EVs alone are sufficient to enter (… the potential mechanisms of cellular damage, we sought to …

… To this end, the hub genes which are likely involved in pathogenicity, were identified based
on the centralities criteria and then enriched in gene ontology biological process and KEGG …