Recurrent de novo mutations in neurodevelopmental disorders: properties and clinical implications

AB Wilfert, A Sulovari, TN Turner, BP Coe, EE Eichler - Genome Medicine, 2017 - Springer
Next-generation sequencing (NGS) is now more accessible to clinicians and researchers.
As a result, our understanding of the genetics of neurodevelopmental disorders (NDDs) has …

[HTML][HTML] Pharmacological differences and clinical implications of various botulinum toxin preparations: a critical appraisal

A Ferrari, M Manca, V Tugnoli, LA Pini - Functional neurology, 2018 - ncbi.nlm.nih.gov
… -1 (TRPV1) in primary dorsal root ganglion neurons, and also of purinergic receptor P2X3. …
a specific acceptor, and does not inhibit the binding of other serotypes to their acceptors. The …

Membrane-initiated estrogen, androgen, and progesterone receptor signaling in health and disease

F Mauvais-Jarvis, CA Lange, ER Levin - Endocrine reviews, 2022 - academic.oup.com
… We also highlight potential clinical implications of pathway-… the cell membrane, binding to
a specific cytoplasmic receptor, … of the steroid-receptor complex to specific “acceptor sites” on …

Transcriptional regulation of antiviral interferon-stimulated genes

W Wang, L Xu, J Su, MP Peppelenbosch, Q Pan - Trends in microbiology, 2017 - cell.com
… evolving field and the clinical implications of recently acquired knowledge in this respect. …
All type I IFNs bind to a common cell-surface receptor, the type I IFN heterodimeric receptor

Fibroblast Growth Factor Receptor 4 (FGFR4) Selective inhibitors as hepatocellular carcinoma therapy: advances and prospects: miniperspective

X Lu, H Chen, AV Patterson, JB Smaill… - Journal of medicinal …, 2018 - ACS Publications
… in trans and mediates cellular effects via downstream MAP … We further detail their clinical
implications, with special attention … inhibitors by incorporating a Michael acceptor on a pan-…

Glycosylation and integrin regulation in cancer

G Marsico, L Russo, F Quondamatteo, A Pandit - Trends in cancer, 2018 - cell.com
… isoforms combine into 24 αβ receptors that act as a bridge between the cell and the ECM
in … and by the ring position (1–6) of the acceptor sugar. The GPI anchor and examples of …

Depression in cancer: the many biobehavioral pathways driving tumor progression

B Bortolato, TN Hyphantis, S Valpione, G Perini… - Cancer treatment …, 2017 - Elsevier
… , the clinical implications of … cell membrane integrity, genetic instability and the formation of
damage associated molecular patterns whose engagement with pattern recognition receptors

GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics

SC Wright, A Motso, S Koutsilieri, CM Beusch… - Nature …, 2023 - nature.com
receptor conformation, functional selectivity, and location bias, thus associating signaling
neighborhoods with functionally distinct cellular outcomes and clinical consequencesacceptor (…

Lipid-modifying therapy in chronic kidney disease: Pathophysiological and clinical considerations

GH Heine, K Eller, JT Stadler, KS Rogacev… - Pharmacology & …, 2020 - Elsevier
… from lipoprotein remnants cleared by hepatic receptors. VLDL triglycerides are cleared from
… In humans, the liver rapidly removes half of the VLDL via the LDL receptor (LDL-R) pathway…

Advances in understanding the pathogenesis of red cell membrane disorders

A Iolascon, I Andolfo, R Russo - British journal of haematology, 2019 - Wiley Online Library
… Red blood cell membrane defects encompass a … defects and their reported clinical
consequences. We also describe … , receptors, signalling molecules and carriers of red cell