Recurrent de novo mutations in neurodevelopmental disorders: properties and clinical implications
Next-generation sequencing (NGS) is now more accessible to clinicians and researchers.
As a result, our understanding of the genetics of neurodevelopmental disorders (NDDs) has …
As a result, our understanding of the genetics of neurodevelopmental disorders (NDDs) has …
[HTML][HTML] Pharmacological differences and clinical implications of various botulinum toxin preparations: a critical appraisal
A Ferrari, M Manca, V Tugnoli, LA Pini - Functional neurology, 2018 - ncbi.nlm.nih.gov
… -1 (TRPV1) in primary dorsal root ganglion neurons, and also of purinergic receptor P2X3. …
a specific acceptor, and does not inhibit the binding of other serotypes to their acceptors. The …
a specific acceptor, and does not inhibit the binding of other serotypes to their acceptors. The …
Membrane-initiated estrogen, androgen, and progesterone receptor signaling in health and disease
… We also highlight potential clinical implications of pathway-… the cell membrane, binding to
a specific cytoplasmic receptor, … of the steroid-receptor complex to specific “acceptor sites” on …
a specific cytoplasmic receptor, … of the steroid-receptor complex to specific “acceptor sites” on …
Transcriptional regulation of antiviral interferon-stimulated genes
… evolving field and the clinical implications of recently acquired knowledge in this respect. …
All type I IFNs bind to a common cell-surface receptor, the type I IFN heterodimeric receptor …
All type I IFNs bind to a common cell-surface receptor, the type I IFN heterodimeric receptor …
Fibroblast Growth Factor Receptor 4 (FGFR4) Selective inhibitors as hepatocellular carcinoma therapy: advances and prospects: miniperspective
X Lu, H Chen, AV Patterson, JB Smaill… - Journal of medicinal …, 2018 - ACS Publications
… in trans and mediates cellular effects via downstream MAP … We further detail their clinical
implications, with special attention … inhibitors by incorporating a Michael acceptor on a pan-…
implications, with special attention … inhibitors by incorporating a Michael acceptor on a pan-…
Glycosylation and integrin regulation in cancer
… isoforms combine into 24 αβ receptors that act as a bridge between the cell and the ECM
in … and by the ring position (1–6) of the acceptor sugar. The GPI anchor and examples of …
in … and by the ring position (1–6) of the acceptor sugar. The GPI anchor and examples of …
Depression in cancer: the many biobehavioral pathways driving tumor progression
… , the clinical implications of … cell membrane integrity, genetic instability and the formation of
damage associated molecular patterns whose engagement with pattern recognition receptors …
damage associated molecular patterns whose engagement with pattern recognition receptors …
GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics
… receptor conformation, functional selectivity, and location bias, thus associating signaling
neighborhoods with functionally distinct cellular outcomes and clinical consequences… acceptor (…
neighborhoods with functionally distinct cellular outcomes and clinical consequences… acceptor (…
Lipid-modifying therapy in chronic kidney disease: Pathophysiological and clinical considerations
… from lipoprotein remnants cleared by hepatic receptors. VLDL triglycerides are cleared from
… In humans, the liver rapidly removes half of the VLDL via the LDL receptor (LDL-R) pathway…
… In humans, the liver rapidly removes half of the VLDL via the LDL receptor (LDL-R) pathway…
Advances in understanding the pathogenesis of red cell membrane disorders
… Red blood cell membrane defects encompass a … defects and their reported clinical
consequences. We also describe … , receptors, signalling molecules and carriers of red cell …
consequences. We also describe … , receptors, signalling molecules and carriers of red cell …