[HTML][HTML] Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion
G Papa, DL Mallery, A Albecka, LG Welch… - PLoS …, 2021 - journals.plos.org
… by binding to the host cell receptor ACE2 and undergoing virus-host … cell types, we observed
that the absence of furin in acceptor … This has important implications for predicting which cell …
that the absence of furin in acceptor … This has important implications for predicting which cell …
[HTML][HTML] Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies
… The mechanisms of toxin-induced tissue damage and their clinical implications are …
also amplify the cell-damaging effect by acting on purinergic receptors in neighbouring cells …
also amplify the cell-damaging effect by acting on purinergic receptors in neighbouring cells …
[PDF][PDF] Innate immune receptors as competitive determinants of cell fate
KM Franz, JC Kagan - Molecular cell, 2017 - cell.com
… This finding suggests that the problems associated with self-non-self-discrimination by the
innate immune system are not simply an academic curiosity but one with clinical implications. …
innate immune system are not simply an academic curiosity but one with clinical implications. …
[HTML][HTML] Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy
A Hamacher-Brady, NR Brady - Cellular and molecular life sciences, 2016 - Springer
… Oxygen (O 2 ) serves as the terminal electron acceptor at complex IV, forming H 2 O. At …
Below we discuss protein mitophagy receptor systems which have been mechanistically …
Below we discuss protein mitophagy receptor systems which have been mechanistically …
[HTML][HTML] Structural biology of SARS-CoV-2 and implications for therapeutic development
H Yang, Z Rao - Nature Reviews Microbiology, 2021 - nature.com
… b,c | Cartoon representations of the RBD in complex with the host cell receptor … acceptor
as a warhead and substituents spanning all substrate-binding subsites. The Michael acceptor …
as a warhead and substituents spanning all substrate-binding subsites. The Michael acceptor …
[HTML][HTML] Dendritic cell–derived exosomes for cancer therapy
… postulated to participate in exosome/acceptor cell interactions (15, 16). … NK cell receptor
expression or functions (notably NKG2D or NKp30), with the predominantly targeted NK receptor …
expression or functions (notably NKG2D or NKp30), with the predominantly targeted NK receptor …
[HTML][HTML] Structures common to different glycans
… discriminate between glycan acceptors with terminal GlcNAc … ABO locus have important
medical implications. Early in the … This assures maximal stimulation of the ovarian LH receptor …
medical implications. Early in the … This assures maximal stimulation of the ovarian LH receptor …
High‐density lipoprotein functionality and breast cancer: A potential therapeutic target
S Samadi, M Ghayour‐Mobarhan… - Journal of Cellular …, 2019 - Wiley Online Library
… attenuated ability of cholesterol acceptor in serum derived from … and SR-BI receptor in two
human cell lines of breast cancer, … cancer cell proliferation based on the clinical implications, …
human cell lines of breast cancer, … cancer cell proliferation based on the clinical implications, …
[PDF][PDF] Systematic analysis of splice-site-creating mutations in cancer
… the functional and the clinical implications of splicing mutations in human disease. … of the
alternative acceptor site would potentially enhance U2AF1 recognition of the acceptor splice site…
alternative acceptor site would potentially enhance U2AF1 recognition of the acceptor splice site…
[HTML][HTML] An aPPARent functional consequence in skeletal muscle physiology via peroxisome proliferator-activated receptors
… Cytoplasmic FABP (FABPc) serves as an acceptor for FFAs, shuttles them through the cellular
compartments, and protects against lipotoxic accumulation and aggregation within the cell …
compartments, and protects against lipotoxic accumulation and aggregation within the cell …