Protective effect of CXCR4 antagonist CX807 in a rat model of hemorrhagic stroke

SJ Yu, KJ Wu, YS Wang, JS Song, CH Wu… - International Journal of …, 2020 - mdpi.com
… CX807 may have clinical implications for the treatment of hemorrhagic stroke. … The PathHunter
® β-Arrestin cell lines expressing chemokine receptors were used. The functional reporter …

The molecular pathogenesis of chronic lymphocytic leukaemia

G Fabbri, R Dalla-Favera - Nature Reviews Cancer, 2016 - nature.com
… 7,8 , probably as a consequence of differences in underlying … CLL HSCs may display a cell
fate skewed towards the B cell … epigenetic abnormalities, B cell receptor (BCR) stimulation …

Soluble immune checkpoints in cancer: production, function and biological significance

D Gu, X Ao, Y Yang, Z Chen, X Xu - Journal for immunotherapy of cancer, 2018 - Springer
… soluble receptors and ligands and discuss related clinical … to the receptors and ligands
of immune checkpoints on cell … by cutting off exon 3, the acceptor site for that variant is 5 bp …

Structural, molecular, and functional alterations of the blood-brain barrier during epileptogenesis and epilepsy: a cause, consequence, or both?

W Löscher, A Friedman - International journal of molecular sciences, 2020 - mdpi.com
… the inductive influence of neighboring cell types, including … , enzymes and receptors regulate
molecular and cellular traffic … hydrogen bond donors and acceptors and the polar surface …

[PDF][PDF] RhoB mediates phosphoantigen recognition by Vγ9Vδ2 T cell receptor

Z Sebestyen, W Scheper, A Vyborova, S Gu… - Cell reports, 2016 - cell.com
… Vg9Vd2 T cell-mediated recognition of cancer (stem) cells. We propose a two-component
mechanism occurring in a tumor cell, which allows Vg9Vd2 T cells to specifically sense cellular

[HTML][HTML] Metabolic implications of oxidative stress and inflammatory process in SARS-CoV-2 pathogenesis: therapeutic potential of natural antioxidants

GE Forcados, A Muhammad, OO Oladipo… - Frontiers in Cellular …, 2021 - frontiersin.org
… SARS-CoV-2 entry into a host cell involves a number of conformational changes requiring
binding of a virus particle to angiotensin-converting enzyme (ACE-2) receptor on the cell

CAR-T cells: the long and winding road to solid tumors

MM D'Aloia, IG Zizzari, B Sacchetti, L Pierelli… - Cell death & …, 2018 - nature.com
… by T-cell activating receptors (accelerators) and inhibitory … of antigen receptors, with significant
implication in predicting the safety … TA sequences in the host DNA act as acceptors of the …

[PDF][PDF] Isolation of a structural mechanism for uncoupling T cell receptor signaling from peptide-MHC binding

LV Sibener, RA Fernandes, EM Kolawole, CB Carbone… - Cell, 2018 - cell.com
… While stimulatory and non-stimulatory ligands can bind to T cell receptors with similar affinity,
only … These non-responsive T cell clones were previously thought to be a consequence of …

ABCG2/BCRP: specific and nonspecific modulators

D Peña‐Solórzano, SA Stark, B König… - Medicinal research …, 2017 - Wiley Online Library
cell line MCF-7/AdrVp, and MXR for its identification in the mitoxantrone (MX) resistant colon
carcinoma cell … In summary, the main clinical implication of specific ABCG2 modulators is …

Fabry disease: molecular basis, pathophysiology, diagnostics and potential therapeutic directions

K Kok, KC Zwiers, RG Boot, HS Overkleeft, JMFG Aerts… - Biomolecules, 2021 - mdpi.com
… mannose-6-phosphate receptor [12]. Due to their medical implications, multiple inhibitors
have … a rational design approach based on donor or acceptor analogues or by high-throughput …