Objectives: Cardiac arrest is associated with morbidity and mortality because of cerebral
ischemia. Therefore, we tested the hypothesis that higher regional cerebral oxygenation
during resuscitation is associated with improved return of spontaneous circulation, survival,
and neurologic outcomes at hospital discharge. We further examined the validity of regional
cerebral oxygenation as a test to predict these outcomes. Design: Multicenter prospective
study of in-hospital cardiac arrest. Setting: Five medical centers in the United States and the …

Recent data suggests that return of spontaneous circulation (ROSC) is associated with
higher regional cerebral oxygen saturation (rSo2) during cardiopulmonary resuscitation
(CPR) in out of hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA).
However, little is known about the optimal level of rSo2 during CPR as well as the optimal
read-out measure from cerebral oximetry monitoring that is prognostic of ROSC or favorable
neurologic outcomes following cardiac arrest (CA). The objectives of this study were to prove …