… in vivo. We hypothesized that exosomal α-synuclein species from … cerebrospinal fluid
from patients with Parkinson’s disease, … dysfunction increases exosome-mediated alpha-synuclein …

… Ultimately, high molecular weight cytosolic fractions enhances … of Lewy body (LB)-associated
αSyn. This study provides evidence from human samples to support previous in vitro and …

… of amplified fibrils to those assembled in vitro by incubation of … TEM images indicates an
increase in fibril diameter with a … cerebrospinal fluid as starting material, have produced Asyn …

… fibril-templating activity in tissues and cerebrospinal fluid (CSF). … At day-in-vitro (DIV) 7,
ssFibrils were added to each well of … across different fibril concentrations to enhance sensitivity. …

… and form the typical intracellular Lewy bodies. Intriguingly, the … To validate the in vitro seeding
capacity of the fibrils, we … 1 μg/μl human alpha synuclein (α-syn) pre-formed fibrils (PFF) or …

… as opposed to Alzheimer’s Disease (AD), in which in vivo investigations using radiotracers …
recombinant α-syn protein, forming amyloid fibrils which enhance fluorescence of thioflavin T (…

… We used several markers of the endocytic pathway fused to the enhanced green fluorescent
protein (EGFP) to determine the mechanisms by which neurons and astrocytes processed …

… presence of intraneuronal inclusions called Lewy bodies (LBs) and Lewy neurites (LNs), …
increases with age. Epidemiological studies have demonstrated that the risk of PD increases …

… vitro seed amplification assays (SAA) detecting misfolded alpha-synuclein (αSyn) in cerebrospinal
fluid (… Alzheimer's disease (AD), is characterized by the misfolding and aggregation of …

… The emerging field of cerebrospinal fluid and molecular imaging … of dementia in LBD and
include studies that have used in vivo … disease and AD co-pathology, may increase the risk of …