An updated view of translocator protein (TSPO)

N Denora, G Natile - International journal of molecular sciences, 2017 - mdpi.com
role of mitochondria in living cells have evidenced the importance of the 18 kDa mitochondrial
translocator protein (TSPOfunction/regulation and apoptosis initiation and that TSPO drug …

The role of translocator protein TSPO in hallmarks of glioblastoma

LM Ammer, A Vollmann-Zwerenz, V Ruf, CH Wetzel… - Cancers, 2020 - mdpi.com
… The 18 kDa translocator protein TSPO is an evolutionary well-conserved … An apoptosis-promoting
role of TSPO is also supported by pharmacological evidence. For instance, …

The 18-kDa translocator protein as a CNS drug target: finding our way through the neuroinflammation fog

MD Filiou, RB Banati… - CNS & Neurological …, 2017 - ingentaconnect.com
Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis
and steroidogenesis as part of the host-defense response. Curr Pharm Des 2007; 13: 2385-405…

VDAC1 and the TSPO: expression, interactions, and associated functions in health and disease states

V Shoshan-Barmatz, S Pittala, D Mizrachi - International journal of …, 2019 - mdpi.com
… that mediates the flux of ions, including Ca 2+ , nucleotides, and metabolites across the
OMM, controls metabolism and apoptosis and interacts with many proteins. This review focuses …

Metal complexes targeting the Translocator Protein 18 kDa (TSPO)

N Denora, RM Iacobazzi, G Natile… - Coordination Chemistry …, 2017 - Elsevier
channel-like structure is mainly located and spanned on the outer mitochondrial membrane,
but TSPO … have shown that some TSPO selective ligands induce apoptosis and cell cycle …

Regulation of translocator protein 18 kDa (TSPO) expression in rat and human male germ cells

G Manku, M Culty - International Journal of Molecular Sciences, 2016 - mdpi.com
… Another important regulatory process is the apoptosis of gonocytes that failed to migrate
and/or differentiate, taking place at the end of the first postnatal week [17]. Studies have …

The 18 kDa Translocator protein (TSPO): cholesterol trafficking and the biology of a prognostic and therapeutic mitochondrial target

M Frison, AK Mallach, E Kennedy… - Molecular basis for …, 2017 - Springer
… but proteins and pathways regulating its efficiency are not yet fully understood. The 18 kDa
protein translocator protein (TSPO)… TSPO is a highly inducible protein which interacts with the …

TSPO: an evolutionarily conserved protein with elusive functions

F Bonsack, S Sukumari-Ramesh - International journal of molecular …, 2018 - mdpi.com
TSPO (18 kDa translocator protein) was identified decades ago in a search for peripheral
tissue binding sites for benzodiazepines, and was formerly called the peripheral …

Cellular sources of TSPO expression in healthy and diseased brain

E Nutma, K Ceyzériat, S Amor, S Tsartsalis… - European journal of …, 2021 - Springer
… The 18 kDa translocator protein (TSPO) is increasingly used as a marker for in vivo …
TSPO in association with VDAC1 has been suggested to have a role in apoptosis, possibly …

Classical and novel TSPO ligands for the mitochondrial TSPO can modulate nuclear gene expression: implications for mitochondrial retrograde signaling

N Yasin, L Veenman, S Singh, M Azrad, J Bode… - International Journal of …, 2017 - mdpi.com
18 kDa translocator protein (TSPO) as well as TSPO ligands modulate various functions,
including functions … Extensive studies have shown that TSPO is involved in apoptosis, gene …