Development and Characterisation of an Immunocompetent Three-Dimensional Oral Mucosal Infection Model

S Gould - 2020 - pearl.plymouth.ac.uk
Oral mucosal models are valuable tools for studying oral infection. Existing models have
been implemented to study … within oral research is the development and optimisation of oral

Organotypic model of the gingiva for studying bacterial and viral pathogens implicated in periodontitis

A Golda, A Gasiorek, E Dobosz, Z Oruba… - Journal of Oral …, 2024 - Taylor & Francis
… and applied to study infections by Porphyromonas gingivalis and … was to optimize an
organotypic gingival model composed of … characteristics. In addition, we assessed whether this …

Three-Dimensional In Vitro Oral Mucosa Models of Fungal and Bacterial Infections

F Tabatabaei, K Moharamzadeh… - Tissue Engineering Part B …, 2020 - liebertpub.com
optimization and standardization with regard to using oral … with Porphyromonas alone or in
association with other … peri-implant oral mucosa in an organotypic model. Cell Microbiol [Epub …

Oral host-microbe interactions investigated in 3D organotypic models

L Shang, D Deng, BP Krom, S Gibbs - Critical reviews in …, 2023 - Taylor & Francis
… in the oral cavity, a review on the existing oral HMI models will … to monitor these microbial
characteristics in real time within … The future 3D oral HMI models should be optimised to include …

A review of co-culture models to study the oral microenvironment and disease

SE Mountcastle, SC Cox, RL Sammons… - Journal of oral …, 2020 - Taylor & Francis
… with the same oral pathogenic species, such as Porphyromonascharacteristics to normal
mucosa when compared with a 2D … biofilms to a 3D organotypic mucosa model. Selecting a co-…

Development and Characterization of In Vitro Human Oral Mucosal Equivalents Derived from Immortalized Oral Keratinocytes

LR Jennings, HE Colley, J Ong… - … Engineering Part C …, 2016 - liebertpub.com
study, we examined whether FNB6 TERT-immortalized oral … histologically similar to normal
oral mucosa and OME based on … by 3D models exposed to Porphyromonas gingivalis with …

Three dimensional oral mucosa models: development and applications

R Sorrentino - 2020 - iris.uniupo.it
… of view, it shares several characteristics with the skin, the dry … with organotypic skin cultures,
full-thickness oral mucosa has … model adding Porphyromonas gingivalis on an oral mucosa

Porphyromonas gingivalis bypasses epithelial barrier and modulates fibroblastic inflammatory response in an in vitro 3D spheroid model

IM Bugueno, F Batool, L Keller, S Kuchler-Bopp… - Scientific Reports, 2018 - nature.com
… For instance, an organotypic mucosal model was developed displaying a well-organized
multi-… -based oral mucosal models (OMM) and displayed efficiently the characteristics of para-…

Tissue engineering of oral mucosa and salivary gland: disease modeling and clinical applications

AA Almansoori, B Kim, JH Lee, SD Tran - Micromachines, 2020 - mdpi.com
… been used to study inflammatory and infection disease models. In one study, the spheroid
model consisting of keratinocyte-fibroblasts was infected with Porphyromonas gingivalis. The …

Developing a 3D organotypical model to assess gum penetrating implant soft tissue outcomes and implant device development

CL White - 2019 - etheses.bham.ac.uk
… This project aimed to develop 3D oral organotypic cultures … Further work is required to
optimise these models to ensure … The oral mucosa is a soft tissue membrane that lines the oral