[HTML][HTML] Appraising the role of astrocytes as suppliers of neuronal glutathione precursors

D Pérez-Sala, MA Pajares - International Journal of Molecular Sciences, 2023 - mdpi.com
… associate with preferential glutathione localization in glial cells … For this purpose, some specific
characteristics of each cell … astrocytes in culture increased extracellular glutathione levels …

Neuronal activity induces glutathione metabolism gene expression in astrocytes

JC McGann, G Mandel - Glia, 2018 - Wiley Online Library
… In this analysis, all expressed genes were first ranked with … nuclear localization and chromatin
binding at glutathione … element (ARE) binding sites for glutathione metabolic genes and …

Glutathione in brain: overview of its conformations, functions, biochemical characteristics, quantitation and potential therapeutic role in brain disorders

D Dwivedi, K Megha, R Mishra, PK Mandal - Neurochemical research, 2020 - Springer
… side) is mediated via Na dependent GSH transporter localized at the luminal membrane.
This GSH from abluminal side en-route astrocyte via Na dependent GSH transporter, which is …

[HTML][HTML] Changes in protein expression and lysine acetylation induced by decreased glutathione levels in astrocytes

M Pehar, LE Ball, DR Sharma, BA Harlan… - Molecular & Cellular …, 2016 - ASBMB
… lysine acetylation in primary astrocyte cultures obtained from wild-… In addition, sequence
analysis of peptides displaying … was >5, and the probability of site localization was above 95%. …

Ebselen alters cellular oxidative status and induces endoplasmic reticulum stress in rat hippocampal astrocytes

P Santofimia-Castaño, A Izquierdo-Alvarez… - Toxicology, 2016 - Elsevier
… SDS-PAGE analysis of the general pattern of protein cysteine oxidation … of glutathione
S-transferase, glutathione reductase, catalase and MDA accumulation. Cultured astrocytes were …

Contribution to the biochemical characterization of astrocytes expressing a mitochondrial-tagged form of catalase

N Bonora - 2018 - gredos.usal.es
… modulate glutathione abundance in primary astrocytes via NRF2 .......................................................................................
111 17. Neurons co-cultured with mROS-weakened astrocytes show …

[HTML][HTML] On the nature of the Cu-rich aggregates in brain astrocytes

B Sullivan, G Robison, J Osborn, M Kay, P Thompson… - Redox Biology, 2017 - Elsevier
… reported localized Cu-rich aggregates in astrocytes of the … glutathione and metallothioneins
– a family of metal-binding, … Thus, we sought to characterize the metal distribution in a MT…

Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral sclerosis

M Kazama, Y Kato, A Kakita, N Noguchi… - …, 2020 - Wiley Online Library
… , to the oxidative form of glutathione (GSSG) once oxidative … enzymatic reaction catalyzed
by glutathione reductase; the … the cultured cells exhibit astrocyte morphology characterized

Role of astrocytes in maintaining cerebral glutathione homeostasis and in protecting the brain against xenobiotics and oxidative stress

AJL Cooper - Glutathione in the nervous system, 2018 - api.taylorfrancis.com
… evidence that astrocytes in culture possess high affinity binding sites for GSH. … Differential
localization of glutathione-5-trBnsferase Yp and … Antisera to glutathione: characterization and …

Metallothionein‐I/II expression associates with the astrocyte DNA damage response and not Alzheimer‐type pathology in the aging brain

R Waller, M Murphy, CJ Garwood, L Jennings… - Glia, 2018 - Wiley Online Library
… In the present study we characterized the immunoreactive … Cultured astrocytes were washed
with PBS and lysed in 110 … is primarily localized in the cytoplasm of astrocytes, however MT-I…