… Biomedical applications of molecules that are able to … Comparative analysis of their predicted
binding mode within … comprising this moiety (eg carazolol) displayed an almost planar …

… Aiming to apply these ligands in future structural and … 49 (B, receptor in light green and the
inverse agonist carazolol in grey). … analysis was performed by normalizing the receptor bound …

… Beta adrenergic receptors (β-AR) undoubtedly belong to the … , synthesis, and pharmacological
characterization of novel β-… 1) were compared to carazolol and those of our previously …

… To characterize the timescale of receptor motions, we … carazolol (PDB 2RH1). In contrast, in
the ternary complexes of agonist-… the beta-adrenergic receptors upon nanobody or G protein …

… Results from the photochemical characterization of the … reported here through the application
of intercalated light cycles at … (A) Rigid docking of carazolol in the empty receptor serves …

… Only in the case of H-3 carazolol were we actually observing … by the analysis of compounds
that are highly protein bound. It … Snyder, SH, Beta adrenergic receptor labeling in intact ani…

… Results from the photochemical characterization of the … applications that require spatiotemporal
activation of specific … the human β2-AR in complex with carazolol (PDB code 2RH1).This …

… with superior decay characteristics (t 1/2 … receptor in the heart and brain by (±)-bisoprolol
leads to faster excretion of labelled (±)-[ 18 F]bisoprolol due to unavailability of receptor binding …

… bound to a diffusible ligand was β2AR, crystallized bound to a high-affinity inverse agonist,
carazolol, in lipid bicelles bound to … We next described and characterized the α2AR in several …

… 68 Figure 1-17 Molecular dynamics simulations of inverse agonist (carazolol) and … Beta
adrenergic receptor δ-OR … The availability of multistate structural data facilitates the application of …