… The Escherichia coli AcrAB-TolC efflux pump is the archetype of the resistance nodulation
cell division (RND) exporters from Gram-negative bacteria. Overexpression of RND-type …

… characterization of the pyranopyridine (Pypy) MBX2319 (Figure 1) as an inhibitor of the
AcrAB efflux pump of E… activity relationships of the pyranopyridine efflux pump inhibitors. By …

… , inhibitors targeting both the efflux transporter AcrB and the membrane fusion protein AcrA in
the Escherichia coli AcrAB-TolC efflux pump … The pyranopyridine compound MBX2319 and …

… Several AcrAB-TolC efflux pump inhibitors (EPIs) have been … pyranopyridines of the MBX
series [[17], [18], [19], [20]]. We recently reported the discovery of a novel class of AcrB inhibitors…

… of the highly efficient pyranopyridine efflux pump inhibitors. Our … In Escherichia coli, the
trimeric efflux pump AcrB is complexed with … coli genome, only AcrAB-TolC reveals constitutive …

… Another EPI that has been the subject of drug discovery efforts targeting AcrAB-TolC is
the pyranopyridine MBX2319 (Figure 7). This compound is chemical derived and has potent …

… NUNL02 was found to be an AcrB efflux pump substrate. … The AcrAB–TolC system present
in Escherichia coli consists of … concentration than that of pyranopyridines MBX2319, MBX3132 …

… a novel chemical scaffold able to boost antibiotic activity in E. coli by inhibiting the AcrAB-TolC
efflux pump. In … Both the pyridopyrimidine and pyranopyridine inhibitors bind to a specific “…

… as those belonging to pyranopyridine, naphthamide and … Other examples of efflux pump
inhibitors from plant sources … to have efflux pump inhibitory activity against the Bmr efflux pump, …

… EPIs active against Escherichia coli or Pseudomonas aeruginosa. … Pyranopyridines were
first described in 2014 by the US company MicroBiotix as AcrAB-TolC efflux pump inhibitors in E…