Cholangiocyte autophagy contributes to hepatic cystogenesis in polycystic liver disease and represents a potential therapeutic target

AI Masyuk, TV Masyuk, MJL Pisarello, JF Ding… - Hepatology, 2018 - journals.lww.com
Notch signaling plays an emerging role in the regulation of immune cell development and
function during inflammatory response. Activation of the ras homolog gene family member
A/Rho‐associated protein kinase (ROCK) pathway promotes leukocyte accumulation in
tissue injury. However, it remains unknown whether Notch signaling regulates ras homolog
gene family member A/ROCK–mediated immune responses in liver ischemia and
reperfusion (IR) injury. This study investigated intracellular signaling pathways regulated by …
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