Pro-inflammatory roles of chondroitin sulfate proteoglycans in disorders of the central nervous system

EL Stephenson, VW Yong - Matrix Biology, 2018 - Elsevier
repair. Here we introduce an extracellular matrix family member that participates in immune-matrix
interactions, the chondroitin sulfate proteoglycans… cells to degrade the parenchymal …

[HTML][HTML] Neural tissue homeostasis and repair is regulated via CS and DS proteoglycan motifs

AJ Hayes, J Melrose - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
… /PNS injury have demonstrated that selective degradation of … roles of chondroitin sulfate
(CS) and dermatan sulfate (DS)-… CNS/PNS and during the development and repair of the CNS/…

[HTML][HTML] Chondroitin sulfates and their binding molecules in the central nervous system

L Djerbal, H Lortat-Jacob, JCF Kwok - Glycoconjugate journal, 2017 - Springer
… core protein to form chondroitin sulfate proteoglycan (CSPG). … of chondrocytes,
metalloproteases degradation of cartilage, … in the maintenance of the ECM structure and their

[HTML][HTML] Proteoglycan sulphation in the function of the mature central nervous system

JW Fawcett, JCF Kwok - Frontiers in Integrative Neuroscience, 2022 - frontiersin.org
Chondroitin sulphate and heparan sulphate proteoglycans (CSPGS and HSPGs) are found
throughout the central nervous system (CNS). … Maintenance of CNS function must depend on …

The emerging role of the chondroitin sulfate proteoglycan family in neurodegenerative diseases

J Lin, M Duan, N Lin, W Zhao - Reviews in the Neurosciences, 2021 - degruyter.com
… response to damage to the central nervous system (CNS). While there are more than 30 …
role in the repair of spinal cord injury and brain injury. In response to CNS injury, astrocytes …

The role of chondroitin sulfate proteoglycans in nervous system development

CP Mencio, RK Hussein, P Yu… - … of Histochemistry & …, 2021 - journals.sagepub.com
… (HSPGs), are one of many players involved in the formation and maintenance of these …
Enzymatic degradation of chondroitin sulfate by ChABC leads fluctuations in dendritic spine size …

Chondroitin sulfate glycosaminoglycan matrices promote neural stem cell maintenance and neuroprotection post-traumatic brain injury

MI Betancur, HD Mason… - ACS biomaterials …, 2017 - ACS Publications
… protects differentiated neurons from degradation after TBI. (23… of the adult and developing
central nervous system (CNS) are … sulfate proteoglycans (HSPGs) the role of CSPGs and their

Chondroitin sulfate metabolism in the brain

D Nowicka, A Gręda - Acta Neurobiologiae Experimentalis, 2019 - ane.pl
… ECM also includes chondroitin sulfate proteoglycans (CSPGs) … CNS, it appears that it can
regulate the composition of PNNs. … As mentioned above, the CS degradation pathway is poorly …

Chondroitin sulfate proteoglycans: key modulators of neuronal plasticity, long-term memory, neurodegenerative, and psychiatric disorders

X Yang - Reviews in the Neurosciences, 2020 - degruyter.com
central nervous system (CNS). They share similar core proteins and are post-transcriptionally
modified by chondroitin sulfate … that the degradation of CSPGs benefits axonal repair. The …

Role of proteoglycans in neuro-inflammation and central nervous system fibrosis

F Heindryckx, JP Li - Matrix Biology, 2018 - Elsevier
chondroitin sulfate proteoglycans (CSPG), heparan sulfate … physical and biochemical
barrier that impedes tissue repair. … Administering a CS breakdown product (oligosaccharides) …