… GSTP1 is commonly down-regulated in prostate tumor … trigger of GSTP1 gene silencing
in prostate cancer remains … , epigenetic changes, including DNA methylation and chromatin …

… is generally associated with a compacted chromatin structure, … in cancer cells and leads to
the transcriptional inactivation … development, we wished to examine the specific changes in …

… ageing of the population and changes in people’s lifestyle habits, the incidence of prostate
… of the GSTP1 promoter in patients with prostate cancer may lead to the inactivation of GSTP1 …

… to open chromatin in the active promoters, with active promoter … Aberrant DNA hypermethylation
results in inactivation of … GSTP1 hypermethylation in prostate samples might be utilized …

… modification and chromatin remodeling changes in gene … , whereas methylation of GSTP1
within CpG dinucleotides … repressor complexes inactivate specific regions of chromatin, …

… activation or by remodeling the chromatin structure. … cancers like human neoplasia, 13
prostate cancer, 14 and breast … Methylation-based inactivation of the GSTP1 gene results in …

… such as mutations and chromosomal rearrangements and global changes to the chromatin
landscape contribute to prostate … Its inactivation triggered genomic instability in sporadic renal …

… The new somatic genome changes play essential role in tumor … of the Epigenome in inactivating
genes whose activity during … , activate chromatin by affecting this gene, and increase its …

… and with renal cancer, and p16 inactivation has been shown … the overexpression of GSTP1
in prostatic epithelial columnar … on chromatin structure, as well as transcriptional initiators and …

… , and epigenetic changes, resulting in the inactivation of tumor… like GSTP1, and HOX family
members, which are related to … and chromatin protein marks are systematically applied to …