… chronic granulocytic leukemia [4], representing the first discovery of a link between chromosomes
and cancer. … clonal evolution, is associated with the advancement of the disease to BC, …

… Yet, challenges to the understanding and management of this disease persist, such as
the newly recognised molecular complexity of chronic myeloid leukaemia, the optimal …

… Although it is hypothesised that additional genomic/genetic alterations are needed for this
evolution, the exact causes have yet to be defined. The answer behind advanced disease may …

… Thus, CML is an ideal system to test our hypothesis that transcriptome-based state-transition
models accurately predict cancer evolution and treatment response. We collected time-…

… disease characteristics have been found to be prognostically useful and have been used to
generate prognostic models… Cancer Cell 2: 117–125. Shah, NP, Skaggs, BJ, Branford, S. et al…

… chronic phase CML phenotype evolved … model of more typical cancer development with
several mutations, here, four mutations. This model is greatly simplified as most human cancers …

… Chronic myeloid leukemia (CML) is a cancer of the … of the disease beginning with the rather
asymptomatic chronic phase and ultimately culminating into blast crisis, an acute leukemia …

… leukaemia/lymphoma (ALL), chronic lymphocytic leukaemia/small lymphocytic lymphoma
(CLL/SLL) and chronic myeloid leukaemia (… In rare cases including during evolution to blast …

… disease, allogeneic transplantation remains the best alternative solution. In general, chronic
myeloid leukemia … the decades thanks to advances in cancer therapy. However, achieving …

… modeling, we add further proof to the concept that chronic inflammation may be both a trigger
of clonal evolution and an important driving force for MPN disease … of cancer development …