Chronic myeloid leukemia: a model disease of the past, present and future
VR Minciacchi, R Kumar, DS Krause - Cells, 2021 - mdpi.com
… chronic granulocytic leukemia [4], representing the first discovery of a link between chromosomes
and cancer. … clonal evolution, is associated with the advancement of the disease to BC, …
and cancer. … clonal evolution, is associated with the advancement of the disease to BC, …
Chronic myeloid leukaemia
J Cortes, C Pavlovsky, S Saußele - The Lancet, 2021 - thelancet.com
… Yet, challenges to the understanding and management of this disease persist, such as
the newly recognised molecular complexity of chronic myeloid leukaemia, the optimal …
the newly recognised molecular complexity of chronic myeloid leukaemia, the optimal …
The biology and pathogenesis of chronic myeloid leukemia
B Chereda, JV Melo - Chronic myeloid leukemia, 2016 - Springer
… Although it is hypothesised that additional genomic/genetic alterations are needed for this
evolution, the exact causes have yet to be defined. The answer behind advanced disease may …
evolution, the exact causes have yet to be defined. The answer behind advanced disease may …
State-transition modeling of blood transcriptome predicts disease evolution and treatment response in chronic myeloid leukemia
DE Frankhouser, RC Rockne, L Uechi, D Zhao… - Leukemia, 2024 - nature.com
… Thus, CML is an ideal system to test our hypothesis that transcriptome-based state-transition
models accurately predict cancer evolution and treatment response. We collected time-…
models accurately predict cancer evolution and treatment response. We collected time-…
Chronic myeloid leukemia
H Kantarjian, J Cortes, E Jabbour… - Molecular …, 2019 - Wiley Online Library
… disease characteristics have been found to be prognostically useful and have been used to
generate prognostic models… Cancer Cell 2: 117–125. Shah, NP, Skaggs, BJ, Branford, S. et al…
generate prognostic models… Cancer Cell 2: 117–125. Shah, NP, Skaggs, BJ, Branford, S. et al…
Is cancer latency an outdated concept? Lessons from chronic myeloid leukemia
M Abecasis, NCP Cross, M Brito, I Ferreira… - Leukemia, 2020 - nature.com
… chronic phase CML phenotype evolved … model of more typical cancer development with
several mutations, here, four mutations. This model is greatly simplified as most human cancers …
several mutations, here, four mutations. This model is greatly simplified as most human cancers …
A causal Bayesian network model of disease progression mechanisms in chronic myeloid leukemia
D Koch, RS Eisinger, A Gebharter - Journal of theoretical biology, 2017 - Elsevier
… Chronic myeloid leukemia (CML) is a cancer of the … of the disease beginning with the rather
asymptomatic chronic phase and ultimately culminating into blast crisis, an acute leukemia …
asymptomatic chronic phase and ultimately culminating into blast crisis, an acute leukemia …
Leukaemia: a model metastatic disease
AE Whiteley, TT Price, G Cantelli, DA Sipkins - Nature Reviews Cancer, 2021 - nature.com
… leukaemia/lymphoma (ALL), chronic lymphocytic leukaemia/small lymphocytic lymphoma
(CLL/SLL) and chronic myeloid leukaemia (… In rare cases including during evolution to blast …
(CLL/SLL) and chronic myeloid leukaemia (… In rare cases including during evolution to blast …
Chronic myeloid leukemia: cytogenetics and molecular biology's part in the comprehension and management of the pathology and treatment evolution
S Benchikh, A Bousfiha, A El Hamouchi… - … of Medical Human …, 2022 - Springer
… disease, allogeneic transplantation remains the best alternative solution. In general, chronic
myeloid leukemia … the decades thanks to advances in cancer therapy. However, achieving …
myeloid leukemia … the decades thanks to advances in cancer therapy. However, achieving …
Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development
M Andersen, Z Sajid, RK Pedersen… - PLoS …, 2017 - journals.plos.org
… modeling, we add further proof to the concept that chronic inflammation may be both a trigger
of clonal evolution and an important driving force for MPN disease … of cancer development …
of clonal evolution and an important driving force for MPN disease … of cancer development …