Chrysin ameliorates STZ-induced diabetes in rats: possible impact of modulation of TLR4/NF-κβ pathway
Background and purpose: Growing evidence advocates that upregulation of toll-like receptor
4 (TLR4) has been suggested as a causative influence in the development and
complications of diabetes mellitus. We aimed to study the antidiabetic activity of chrysin
against streptozotocin (STZ)-induced diabetes via down-regulation of TLR4/nuclear factor
(NF-κβ)/heat shock protein 70 (HSP70) pathway as well as modulation of clusters of
differentiation 4 (CD4+) in rats. Experimental approach: Fifty rats were divided into five …
4 (TLR4) has been suggested as a causative influence in the development and
complications of diabetes mellitus. We aimed to study the antidiabetic activity of chrysin
against streptozotocin (STZ)-induced diabetes via down-regulation of TLR4/nuclear factor
(NF-κβ)/heat shock protein 70 (HSP70) pathway as well as modulation of clusters of
differentiation 4 (CD4+) in rats. Experimental approach: Fifty rats were divided into five …
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