[HTML][HTML] Hydroquinone exposure worsens rheumatoid arthritis through the activation of the aryl hydrocarbon receptor and interleukin-17 pathways

CS Heluany, PB Donate, AH Schneider, AL Fabris… - Antioxidants, 2021 - mdpi.com
… were measured in RA human fibroblast-like synoviocytes (… is activated by pro-inflammatory
cytokines that facilitate the … As expected, the TNF-α treatment promoted the upregulation of NF-…

[HTML][HTML] The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases

S Wang, H Wang, C Feng, C Li, Z Li, J He, C Tu - Cell Death Discovery, 2022 - nature.com
proinflammatory cytokines also lead to the upregulation of … Caspase-8 acts as the bridge in
the crossing lines of apoptosis… the apoptosis of fibroblast-like synoviocytes (FLSs) and CD4+ …

Emerging epigenetic targets in rheumatoid arthritis

RR Barik, LK Bhatt - Rheumatology International, 2021 - Springer
… and increases the vascularity and infiltration of immune cells, hence activating the fibroblast-like
… with its ligand upregulates the expression of proinflammatory cytokines. Inhibiting CD99 …

A molecular insight of inflammatory cascades in rheumatoid arthritis and anti-arthritic potential of phytoconstituents

V Patidar, S Shah, R Kumar, PK Singh, SB Singh… - Molecular Biology …, 2022 - Springer
… , induction of the apoptosis of fibroblast-like synoviocytes (FLS), … inflamed synovium induces
IL-1β protein and NLRP3 expression, … The elevated levels of pro-inflammatory cytokines is …

[PDF][PDF] Österreichischen Gesellschaft für Rheumatologie & Rehabilitation 1.–3. Dezember 2016

A Pathophysiologie - rheumatologie.at
… -A2/B1 in human fibroblast-like synoviocytes (FLS). Materials and … of pro-inflammatory
cytokine expression in immune cells. … of tocilizumab with methotrexate induces a better outcome (…

[PDF][PDF] BRD3 Regulates the Inflammatory and Stress Response in Rheumatoid Arthritis Synovial Fibroblasts. Biomedicines 2023, 11, 3188

T Seifritz, M Brunner, E Camarillo Retamosa… - 2023 - scholar.archive.org
… of large amounts of pro-inflammatory cytokines, chemokines, … genes escape repression
in fibroblast-like synoviocytes: … Smoking induces transcription of the heat shock protein

Rheumatoid arthritis: advances in treatment strategies

P Prasad, S Verma, Surbhi, NK Ganguly… - Molecular and cellular …, 2023 - Springer
expression of MMP1, 3 and 15 in fibroblast-like synoviocytes. … Therefore, inhibiting pro-inflammatory
cytokines or … In RA patients, upregulation of miR-146a causes persistent production

Studies on the perturbations of CD4+ T cells function by cigarette smoke.

A Alghamdi - 2023 - etheses.bham.ac.uk
Protein expression and phosphorylation were assessed … (eg smoking and infection) and
genetic (eg protein tyrosine … found to upregulate the production of pro-inflammatory cytokines (IL-…

Nicotine and autoimmunity: The lotus' flower in tobacco

JP Gomes, A Watad, Y Shoenfeld - Pharmacological research, 2018 - Elsevier
… suggest that increases pro-inflammatory cytokines and provokes … to mice receiving cigarette
smoke condensate, which experienced … Genetic and environmental factors contribute to the …

[HTML][HTML] Anti-arthritic and anti-cancer activities of polyphenols: A review of the most recent in vitro assays

M Ali, V Benfante, A Stefano, A Yezzi, D Di Raimondo… - Life, 2023 - mdpi.com
… by excessive production of proinflammatory cytokines secrete … of grapes [93] and that increases
the expression of heme oxygenase-1 (… of MMP-3 and IL-1b in fibroblast-like synoviocytes. …