[HTML][HTML] DNA methylation-governed gene expression in autoimmune arthritis

B Brandt, S Rashidiani, Á Bán, TA Rauch - International journal of …, 2019 - mdpi.com
… MeCP2 can increase chromatin condensation by recruiting histone … Accordingly, IL6 is a
pro-inflammatory cytokine that stimulates … Accordingly, the upregulated ZBTB38 could bind to the …

Epigenetics in health and disease

L Zhang, Q Lu, C Chang - Epigenetics in allergy and autoimmunity, 2020 - Springer
… This results in abnormal chromatin condensation and … cell division in lung cell lines and
upregulation inhibits cell growth. … to downregulation of pro-inflammatory cytokines, such as IL-6…

Citrullination and autoimmunity

G Valesini, MC Gerardi, C Iannuccelli, VA Pacucci… - Mosaic of …, 2019 - Elsevier
… cells promote secretion of proinflammatory cytokines (ie, IL-1… reprogram their gene expression
profile, upregulate chemokine … apoptosis of RA fibroblast-like synoviocytes is pivotal in the …

Impact of secondhand smoking on disease activity in women with rheumatoid arthritis

N Hammam, TA Gheita - Clinical Rheumatology, 2017 - Springer
smoking with a genetic background [2]. RA is characterized by the production of proinflammatory
cytokines… its pathogenesis with upregulated effect of cigarette smoke indicating a strong …

Survivin modulatory role in autoimmune and autoinflammatory diseases

Y Pahlavan, H Kahroba, N Samadi… - Journal of cellular …, 2019 - Wiley Online Library
fibroblast-like synoviocyte (FLS) activation beside production of several proinflammatory
cytokines in … level of survivin is upregulated in certain pathological condition especially in AIDs …

[HTML][HTML] Smoking and Rheumatoid Arthritis: A Case for Smoking Cessation

H Fosam - 2016 - rheumatologyadvisor.com
Cigarette smoke condensate has also been shown to induce the production of proinflammatory
cytokines … factor (TNF)-α in fibroblast-like synoviocytes affected by RA. Among these, IL-1 …

[HTML][HTML] Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy

X Xuan, L Zhang, C Tian, T Wu, H Ye, J Cao, F Chen… - Cell & bioscience, 2021 - Springer
… a variety of proinflammatory cytokines and chemokines, may … Fibroblastlike synoviocytes
(FLSs) act as a bridge between the … and the expression of MCP-1 was upregulated after IL-22 …

[HTML][HTML] The anti-inflammatory properties of phytochemicals and their effects on epigenetic mechanisms involved in TLR4/NF-κB-mediated inflammation

HA Saleh, MH Yousef, A Abdelnaser - Frontiers in immunology, 2021 - frontiersin.org
… , DNA hyper-methylation induces chromatin condensation (… also induces coupling with
other gene repressing proteins … reduces the production of proinflammatory cytokines via MAP …

Cellular and molecular mechanisms of curcumin in prevention and treatment of disease

SS Patel, A Acharya, RS Ray, R Agrawal… - Critical reviews in …, 2020 - Taylor & Francis
… Curcumin treatment upregulated the gene expression of … pro-fibrotic and pro-inflammatory
cytokines. Additionally, curcumin … in MH7A cells and Fibroblast-like synoviocytes. In addition, it …

[HTML][HTML] Preclinical and clinical progress for HDAC as a putative target for epigenetic remodeling and functionality of immune cells

S Zhang, L Zhan, X Li, Z Yang, Y Luo… - International journal of …, 2021 - ncbi.nlm.nih.gov
… residues, thus promoting DNA condensation, and therefore, … decreased the production of
proinflammatory cytokines 86 . … Hodgkin lymphoma cells induces expression of OX40 ligand, …