[HTML][HTML] Smoking and Rheumatoid Arthritis: A Case for Smoking Cessation

H Fosam - 2016 - rheumatologyadvisor.com
Cigarette smoke condensate has also been shown to induce the production of proinflammatory
cytokines … factor (TNF)-α in fibroblast-like synoviocytes affected by RA. Among these, IL-1 …

Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy

S Zhang, Y Meng, L Zhou, L Qiu, H Wang, D Su… - MedComm, 2022 - Wiley Online Library
… histones, resulting in the condensation of chromatin and the … further induces the expression
of proinflammatory cytokines and … METTL3 triggers fibroblast-like synoviocyte activation and …

Triterpenes as Potential Drug Candidates for Rheumatoid Arthritis Treatment

C Faustino, L Pinheiro, N Duarte - Life, 2023 - mdpi.com
… methylome pattern of RA fibroblast-like synoviocytes (FLSs) … formation with production of
pro-inflammatory cytokines (eg, … Bcl-2 protein expression while upregulating Bax, caspase-3 …

Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis

AR Phull, B Nasir, I ul Haq, SJ Kim - Chemico-biological interactions, 2018 - Elsevier
Pro-inflammatory cytokines primarily TNF-α, IL-1 and IL-6 are … and lipid peroxidation, and
increases the danger of inflammation … Cultured RA fibroblast-like synoiocytes and RA synovium …

Epigenetic regulation of inflammation in periodontitis: cellular mechanisms and therapeutic potential

KT Jurdziński, J Potempa, AM Grabiec - Clinical epigenetics, 2020 - Springer
… or Treponema denticola induces alterations in expression and … It typically causes
chromatin condensation and disruption of … in gingival fibroblasts and the GEC line TIGK (telomerase-…

Mitogen-and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states

H Sattarifard, A Safaei, E Khazeeva… - … and Cell Biology, 2023 - cdnsciencepub.com
… mutated genes in lung cancer, induces the expression of ETS … stimulated human primary
cultured fibroblast-like synoviocytes… increased production of pro-inflammatory cytokines leading …

Recent advances in understanding the pathogenesis of rheumatoid arthritis: new treatment strategies

AL Mueller, Z Payandeh, N Mohammadkhani… - Cells, 2021 - mdpi.com
… , intracellular calcium concentration increases to levels far … , which are involved in chromatin
condensation, repression of … capability for pro-inflammatory cytokine production including …

Spotlight on NLRP3 inflammasome: role in pathogenesis and therapies of atherosclerosis

C Jiang, S Xie, G Yang, N Wang - Journal of Inflammation …, 2021 - Taylor & Francis
… the release of pro-inflammatory cytokines and launches … -induced arthritis fibroblast-like
synoviocytes. Citation101 … constituent of tobacco, acrolein, induces NLRP3 inflammasome-…

Phytotherapeutic approach: a new hope for polycyclic aromatic hydrocarbons induced cellular disorders, autophagic and apoptotic cell death

DN Das, PK Panda, PP Naik… - Toxicology …, 2017 - Taylor & Francis
… a]P induces apoptosis in the rat hepatic epithelial F258 cell line … in many cancer-related
genes can disrupt the apoptosis … Likewise, exposure to cigarette smoke induces dysfunction of …

Sirtuins and Cellular Senescence in Patients with Idiopathic Pulmonary Fibrosis and Systemic Autoimmune Disorders

V D'Agnano, DF Mariniello, R Pagliaro, MS Far… - Drugs, 2024 - Springer
… pathway induces the expression of proinflammatory genes, … Type B synoviocytes, called
fibroblast-like synoviocytes (FLS)… proinflammatory cytokines monocyte chemoattractant protein-1…