… smoking and increased risk of developing a breast carcinoma [5,6,7]. It has been proposed
that tobacco smoke … In vitro studies have proposed that cigarette smoke induces the epithelial …

… cytokine and chemokine production and upregulate T-… , suppressed the production of MMPs
from fibroblast-like synovial … , could inhibit the production of pro-inflammatory cytokines IL-6 …

… Cigarette smoke condensate upregulates the gene and protein expression of
proinflammatory cytokines in human fibroblastlike synoviocyte line. Journal of Interferon & …

… system of cultured fibroblast-like synoviocytes within a biochip in … Genes in blue are down-,
genes in red upregulated in week 1. (C) … experiments, performed with 6 different cell lines. …

… the authors found that the hub protein IRF7 is upregulated in COVID-19 … , proinflammatory
cytokines are increased, anti-inflammatory … but not in stromal fibroblast-like synoviocytes (150). …

… by fibroblast-like synoviocytes (FLSs) and macrophage-like … increases the expression of other
pro-inflammatory cytokines. … to the reconstitution of multiple human cell lines. However, the …

… ) were used to modulate the expression levels of target genes implicated by the prioritised
… any surrounding genes. However, a modest yet statistically significant upregulation of ICA1L …

… TGF-β1 treatment upregulated the expression of the KDM5 … , we observed profound
changes in genes that regulate the PI3K-… Fibroblast like synoviocytes (FLS) are another strong …

… and the production of pro-inflammatory cytokines and other mediators … suppress gene
transcription via chromatin condensation, … In conclusion, SIRT3 mRNA expression increases in …

… be induced in co-cultures with fibroblast-like synoviocytes. … Furthermore, gene expression
analysis supports a heightened … are the main producers of pro-inflammatory cytokines (47). …