… mechanisms of myeloid cell migration and settlement into … populations in the CNS stem
from embryonic precursors (Fig. … bone marrow and not from blood circulation 64 . Altogether, …

… erythromyeloid precursors and migrate to the brain during … , circulating myeloid cells migrate
into the brain parenchyma … the pathogenesis of these diseases [53], although their role as …

… significant players in the pathogenesis of various diseases. … of Ly-6C hi cells remains in an
immature state within the CNS… the enrichment of circulating CD11b + Ly-6C hi Ly-6G low/int …

… and independently of circulating precursors. For instance, the … and myeloid cells in the central
nervous system (CNS) and is … in host defense against pathogens and antitumor immunity. …

… motile CNS myeloid cells that function as the first line of defense against invading pathogens.
… received from the parenchyma with signals coming from circulating immune cells (33–35). …

… in bone marrow and circulate through blood vessels and patrol … to the control of pathogen
proliferation during infection [11]. … in the inflamed central nervous system, as their migration and …

… These myeloid cells in the CNS parenchyma and at CNS–… impairs the migration of
autoreactive lymphocytes to the CNS, … The pathogenic role of circulating Ly-6C hi CCR2 + …

… Although myeloid APCs play a prominent role in the pathogenesis of … In addition, it has
been shown that CCR2 + Ly-6C hi … Circulating Ly6C hi monocytes traffic across the blood-brain …

… are released from activated neutrophils to entrap pathogens [38]. NETs are also … circulating
myeloid cells are Ly-6C hi CCR2 + cells; only these are able to infiltrate into the injured brain…

… Their functions include the killing of pathogens via … and Ly-6C hi monocytes are thought to
give rise to Ly-6C lo … subset recruited from the circulation into the ischemic brain in mice. As to …