Citalopram prevents sleep-deprivation-induced reduction in CaMKII-CREB-BDNF signaling in mouse prefrontal cortex
A Misrani, S Tabassum, M Wang, J Chen, L Yang… - Brain Research …, 2020 - Elsevier
Curtailment of sleep in modern society leads to a spectrum of neuropsychiatric disorders.
However, the molecular mechanisms underlying the effects of sleep deprivation (SD) remain
elusive and currently there is no effective therapy to alleviate these effects. Here, we aimed
to examine SD-induced cellular and molecular alterations in mouse prefrontal cortex (PFC)
and whether subchronic citalopram (CTM) treatment can negate these alterations. Three-
month-old C57BL/6 J mice were divided into control (Ctrl), SD, CTM alone and CTM+ SD …
However, the molecular mechanisms underlying the effects of sleep deprivation (SD) remain
elusive and currently there is no effective therapy to alleviate these effects. Here, we aimed
to examine SD-induced cellular and molecular alterations in mouse prefrontal cortex (PFC)
and whether subchronic citalopram (CTM) treatment can negate these alterations. Three-
month-old C57BL/6 J mice were divided into control (Ctrl), SD, CTM alone and CTM+ SD …
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