… sites, which are distinct from those of the other serine β-lactamases. Their substrate profile
is … This review aims to describe the current class D β-lactamases including the functional …

… -spectrum β-lactamases (ESBLs) and the serine and metallo-carbapenemases, all of which
… A and B enzymes in Gram-positive bacilli described a set of oxacillin-hydrolyzing (class D) …

… the carbapenemase activity of class D β-lactamases (11). Evaluation of the carbapenemase
activity of other class D … carbapenemase activity that equals that of some known CHDLs (12). …

… on those reviews and highlight the role of carbapenemases as … of class D β-lactamases,
which are able to hydrolyze amino- and carboxypenicillins. The majority of class D β-lactamases …

… Here we demonstrate that efficient class D β-lactamases … Class D enzymes of Gram-positive
bacteria have a distinct … that of all currently known class A, C and D β-lactamases. These …

… carbapenemase catalysis proceeds through hydrolysis of an acyl-enzyme intermediate. We
show that class D β-lactamases … We show that the class D β-lactamases employ a previously …

… serine βlactamases of all classes [38, 39]. The OXA-24 and OXA-48 complexes with avibactam
show the inhibitor covalently bound to the catalytic serine upon hydrolysis of the CN bond …

… between class D and class A or class C β-lactamases is only … Carbapenem-hydrolyzing class
D β-lactamases (CHDLs) are … Similar to class A β-lactamases, class D β-lactamases retain …

… Class D enzymes are all termed oxacillinase (OXA); … is then how class A β-lactamases
with carbapenemase activity, … that they are distinguished from other class A β-lactamases by …

… Clinically-relevant carbapenemases belong either to metallo-β- lactamases (MBLs) of
Ambler class B or to serine-β-lactamases (SBLs) of Ambler class A and D enzymes. …