… is growing by an increasing number of clinical trials and animal studies. This article provides
an overview of the current clinical applications of S. marianum in the oncology setting, …

… limits their clinical applications. Silybum marianum (SM), belonging to the genus Silybum of
… gastric cancer silymarin 20–120 mg/L AGS human gastric cancer cells inhibits growth and …

… Although, the plant is available for use as a dietary supplement, the FDA did not yet approve
its use for cancer therapy. Nowadays, clinical investigations are in progress where a global …

… to prevent cancer by inducing apoptosis in cancer cells … , suppressing cell proliferation, and
cancer-promoting angiogenesis, … Silybum marianum L., known as milk thistle, has been used …

… The medical use of milk thistle has an extensive history. Theophrastus (c.371-287 BC), a
Greek … A decoction of it is said to be beneficial as an external application in cancer. Leaves: …

… The medical use of MT was reported in the Middle Age in the … and silybin suppressed the
growth of cancer liver cells. Interestingly, a … By using carcinogenic models of hepatic cancer for …

… These findings proved its hypoglycemic effect and paved the way for its possible clinical
use … regarding the clinical significance of Silybum marianum concludes its pharmacological …

… Further studies, particularly clinical trials, to test milk thistle either as a potential treatment …
proliferation and promoted apoptosis in different oral cancer cell lines in a dose dependent …

… Silybum marianum seeds contain a family of flavonolignans which can regulate cancer cell
… Additional pre-clinical and clinical investigations are needed to confirm the anti-HCC effects …

… Silymarin is a complex extract isolated from the plant Silybum marianum, widely known for
its prominent antioxidant and hepatoprotective effects, although increasing evidences have …