Antifungal agents: spectrum of activity, pharmacology, and clinical indications

JE Nett, DR Andes - Infectious Disease Clinics, 2016 - id.theclinics.com
… The currently available antifungal agents vary significantly in terms of spectrum of activity.
The echinocandins exhibit potent activity against Candida, whereas the newer triazoles offer …

[HTML][HTML] Adverse effects associated with currently commonly used antifungal agents: A network meta-analysis and systematic review

YL Yang, ZJ Xiang, JH Yang, WJ Wang… - … in Pharmacology, 2021 - frontiersin.org
… of AEs associated with nine commonly used antifungal agents was conducted. A total of …
antifungal agent tolerability, clinical AEs and laboratory AEs. Meanwhile, a subgroup analysis

Antifungals in clinical use and the pipeline

MD Johnson - Infectious Disease Clinics, 2021 - id.theclinics.com
… The ideal antifungal agent in regard to spectrum of activity, pharmacokinetic/… This article
reviews pharmacologic aspects of currently available systemic antifungal agents in use for …

Antifungal agents and the kidney: pharmacokinetics, clinical nephrotoxicity, and interactions

A Tragiannidis, A Gkampeta, M Vousvouki… - Expert opinion on …, 2021 - Taylor & Francis
… A detailed analysis of various trials and a larger number of meta-analyses concluded that …
appropriate, polyene antifungal agents may be avoided and alternative agents may be used, …

Administration and dosing of systemic antifungal agents in pediatric patients

KJ Downes, BT Fisher, NR Zane - Pediatric Drugs, 2020 - Springer
… of antifungals in children are limited. This paper reviews the spectra of activity for approved
antifungal agents … regarding the current state of antifungal clinical pharmacology in pediatrics. …

Clinical hepatotoxicity associated with antifungal agents

I Kyriakidis, A Tragiannidis, S Munchen… - Expert opinion on drug …, 2017 - Taylor & Francis
… This article reviews current data on drug-induced hepatotoxicity of antifungal agents used
for … pharmacological interventions, a thorough understanding of hepatic adverse effects of …

Pharmacokinetics–pharmacodynamics of antifungal agents in the central nervous system

KE Stott, W Hope - Expert Opinion on Drug Metabolism & …, 2018 - Taylor & Francis
… preclinical and clinical data that quantify antifungal pharmacokinetics (… clinical use of existing
antifungal drugs, and introduces novel … and use of antifungal drugs for CNS fungal disease. …

[PDF][PDF] Building a clinical pharmacology framework for the safe and effective use of antifungal agents

VJC Lempers - 2016 - repository.ubn.ru.nl
antifungal agents Despite research that has been conducted in the field of clinical pharmacology
of antifungal drugs, … of the clinical pharmacology of antifungal drugs in order to optimize …

[HTML][HTML] Antifungals: From Pharmacokinetics to Clinical Practice

A Carmo, M Rocha, P Pereirinha, R Tomé, E Costa - Antibiotics, 2023 - mdpi.com
… In addition to the pharmacological properties of the antifungal drugs, our review also … in
order to be aware of the existence of antifungal resistance. The adequate knowledge of the …

Therapeutic drug monitoring of systemic antifungal agents: a pragmatic approach for adult and pediatric patients

J John, A Loo, S Mazur, TJ Walsh - Expert opinion on drug …, 2019 - Taylor & Francis
… considerations for TDM of select antifungal agents. The objective of this review is to describe
the rationale for TDM, … General clinical pharmacology considerations for pediatric studies for …