… the key mechanism protecting pituitary adenomas turning malignant in the … Here we briefly
summarize the genetic background of pituitary adenomas, … Clonal origin of pituitary adenomas …

… pituitary adenomas can be observed in AIP gene mutation-positive cases and in X-linked
acrogigantism due to GPR101 duplications, but in most familial isolated pituitary adenomas, …

… adenoma), in which distinct double pituitary adenoma was … Double pituitary masses of
different origin (eg, adenoma and … populations of different clonal origin were also recognized (…

… heterogeneous clonal landscape of GH-secreting pituitary adenomas. Whether the molecular
stratification based on CNAs represents a new prognostic tool remains to be determined …

… Associations of pituitary adenomas with other tumors have … -paraganglioma with pituitary
adenoma association (3PAs) … molecular pathophysiology in pituitary adenomas is a key …

… Traditional histopathology suggests that pituitary adenomas arise from clonal proliferation,
and molecular markers and X-chromosome inactivation are distributed homogeneously …

… Overall, the genomic studies of pituitary adenomas sug gest that pituitary adenomas are …
with special reference to multihormone production and clonality of the adenomas. Cancer 95…

… Pituitary adenomas are benign neoplasms that are found in up to 20% of pituitaries … pituitary
adenomas occur in approximately 1:1000 people (2). Usually they are monoclonal in origin, …

… suggesting the existence of tumor stem cells in mouse and human pituitary tumors. Finally, …
, in which the oncogenically transformed CSC gives rise to the tumor clonally. Interestingly, …

… pathogenesis of pituitary adenomas may yield novel therapeutic targets. Although pituitary
adenomas are likely monoclonal in origin, ubiquitous … Clonal origin of pituitary adenomas. …