Key transcription factors mediating cocaine-induced plasticity in the nucleus accumbens

CD Teague, EJ Nestler - Molecular psychiatry, 2022 - nature.com
… of a gene’s expression but instead alter the transcriptional response of the gene to a future
… in NAc neurons increases cocaine-induced reward, locomotor sensitization, and dendritic …

[HTML][HTML] Dynamic expression changes in the transcriptome of the prefrontal cortex after repeated exposure to cocaine in mice

M Li, P Xu, Y Xu, H Teng, W Tian, Q Du… - Frontiers in …, 2017 - frontiersin.org
… pathway had similar dynamic changes after cocaine withdrawal (r > 0.70, p < 0.05), indicating
that interaction between these two pathways mediated cocaine-induced neuroadaptations. …

Cocaine self-administration alters transcriptome-wide responses in the brain's reward circuitry

DM Walker, HM Cates, YHE Loh, I Purushothaman… - Biological …, 2018 - Elsevier
… those genes positively and negatively associated with AI in all … , the transcriptional response
of genes associated with AI is … controlling region-specific cocaine-induced gene expression. (…

[HTML][HTML] Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation

SL Cole, R Chandra, M Harris, I Patel, T Wang, H Kim… - Molecular Brain, 2021 - Springer
… into cocaine-induced transcriptional mechanisms and their … transcription factor, early growth
response factor 3 (Egr3), to nuclear genes involved in mitochondrial function and dynamics. …

Cocaine-induced behavioral sensitization decreases the expression of endocannabinoid signaling-related proteins in the mouse hippocampus

E Blanco, P Galeano, A Palomino, FJ Pavon… - European …, 2016 - Elsevier
… Negative controls included reverse transcription reactions that omitted the reverse
transcriptase. The obtained cDNAs were used as templates for quantitative real-time PCR with an …

A dopamine-induced gene expression signature regulates neuronal function and cocaine response

KE Savell, JJ Tuscher, ME Zipperly, CG Duke… - Science …, 2020 - science.org
sensitization in vivo. Together, these results define the … contributed to behavioral or
transcriptional responses to cocaine, … -cell resolution of cocaine-induced transcriptional regulation …

Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens

P Mews, L Sosnick, A Gurung, S Sidoli, EJ Nestler - Science Signaling, 2024 - science.org
… In this study, we systematically investigated cocaine-induced proteomic alterations within …
-associated. Using a murine model, we assessed the immediate proteomic responses in …

Dopamine-Dependent Transcriptional Dynamics in Striatal Physiology and Cocaine Reward

ME Zipperly - 2020 - search.proquest.com
… -dependent DNA methylation dynamics and cocaine reward memory. Overall, these data
suggest that cocaine triggers a rapid transcriptional response in specific neuronal populations …

[HTML][HTML] DNA methylation dynamics and cocaine in the brain: progress and prospects

K Vaillancourt, C Ernst, D Mash, G Turecki - Genes, 2017 - mdpi.com
sensitization in rats [37]. Importantly, methyl supplementation had no effect on the acute
locomotor response to … suggests that cocaine-induced methylation dynamics are associated with …

Transcriptomics and Cocaine Addiction

YM Contreras, TA Green - Handbook of Substance Misuse and Addictions …, 2022 - Springer
… One of the most vigorous transcriptional responses following … cocaine-induced transcriptional
changes that are associated … nucleus accumbens of cocaine-sensitized rats is enabled by …