Hemodynamic changes may provide important information for clinical decision‑making in internal carotid artery (ICA) stenosis. The degree of stenosis is responsible for the hemodynamic changes. For detection of intracranial stenosis, each diagnostic method has its own advantages and disadvantages. The goal of the present study was to compare the sensitivity and accuracy of color‑coded duplex sonography with that of magnetic resonance angiography (MRA) for the detection of intracranial stenosis. Patients with 3 vessels and/or left stem coronary artery disease were subjected to transcranial and extracranial color‑coded duplex sonography (n= 998), MRA (n= 998) and invasive catheter angiography (n= 939). The degree of stenosis was defined according to the Warfarin‑Aspirin Symptomatic Intracranial Disease methodology. A≥ 50% reduction in artery diameter was considered as a positive obstructive lesion. The benefits of each imaging method were assessed by clinical decision‑making analysis. Color‑coded duplex sonography and MRA, had sensitivities of 0.935 and 0.957 and accuracies of 0.92 and 0.974, respectively, when using invasive catheter angiography as a gold standard. The number of false‑positive obstructive lesions detected by MRA was significantly higher than that for color‑coded duplex sonography (53 vs. 13, P< 0.0001). Color‑coded duplex sonography was able to detect an obstructive lesion in one single image for ICAs with≥ 57% stenosis, while MRA was only capable of detecting an obstructive lesion in one single image for ICAs with≥ 80% stenosis. In conclusion, color‑coded duplex sonography is a reliable method for the detection of intracranial stenosis in patients with coronary artery disease.