[HTML][HTML] The synergism of natural compounds and conventional therapeutics against colorectal cancer progression and metastasis

Z Liang, H Xie, W Shen, L Shao, L Zeng… - Frontiers in Bioscience …, 2022 - imrpress.com
… It also showed more significant cell growth delay and … growth of HCT 116 cancer cells
in an additive or synergistic … and 5-FU induces apoptosis in colon cancer cells and re-sensitizes …

Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer: critical role of p53

M Terranova-Barberio, B Pecori, MS Roca… - … & Clinical Cancer …, 2017 - Springer
… HDACi, such as VPA and vorinostat, are able to induce apoptosis independently of p53
status, while for others, such as entinostat, p53 is crucial for their activity [40, 41]. However, …

[HTML][HTML] Synergistic antitumor effect of 5-fluorouracil and withaferin-A induces endoplasmic reticulum stress-mediated autophagy and apoptosis in colorectal cancer …

AM Alnuqaydan, B Rah, AG Almutary… - … Journal of Cancer …, 2020 - ncbi.nlm.nih.gov
induces autophagy and apoptosis via ER stress in CRC cells. … mode of cell killing but also
induces apoptosis to reduce the cell … the progression of the cell cycle and reaches the optimum

Sanguisorba officinalis L synergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cells by promoting a reactive oxygen species-mediated, mitochondria …

M Liu, M Liao, C Dai, J Chen, C Yang, M Liu, Z Chen… - Scientific reports, 2016 - nature.com
… breast cancer cells by inducing apoptosis and cell cycle arrest via … was involved in synergistic
apoptosis in RKO cells, which … underlying mechanism and the optimized combination of the …

Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer

PA Clarke, T Roe, K Swabey, SM Hobbs, C McAndrew… - Oncogene, 2019 - nature.com
… a synergistic inhibition of growth in almost all cell lines. … We find that BCLXL siRNA induced
apoptosis when combined with … response to the optimal MEK−PI3K inhibitor combination …

Synergistic anti-tumor effect of mTOR inhibitors with irinotecan on colon cancer cells

D Reita, C Bour, R Benbrika, A Groh, E Pencreach… - Cancers, 2019 - mdpi.com
… Based on the aforementioned in vitro results showing the better efficacy of catalytic inhibitors
over rapamycin to inhibit viability of colon cancer cells when used alone, we next evaluated …

[HTML][HTML] Inhibition of autophagy amplifies baicalein-induced apoptosis in human colorectal cancer

T Phan, VH Nguyen, MA Salazar, P Wong… - Molecular Therapy …, 2020 - cell.com
… In HCT-116 there was synergy between baicalein and CQ (Figure 2B). The increasing … to
optimize the bioavailability of baicalein. Baicalein has been shown to induce apoptosis with an …

Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib

CS Wu, SY Wu, HC Chen, CA Chu, HH Tang… - The Journal of …, 2019 - Elsevier
colorectal cancer HT-29 cells (KRAS wild-type), producing an additive or synergistic effect
in HCT 116 cells … enhances chemosensitivity and induces apoptosis by interacting with …

Repurposing of niclosamide as a STAT3 inhibitor to enhance the anticancer effect of chemotherapeutic drugs in treating colorectal cancer

MM Wu, Z Zhang, CWS Tong, VVW Yan, WCS Cho… - Life Sciences, 2020 - Elsevier
… survivin and cyclin-D1 to induce apoptosis and cell cycle arrest. … synergistic anticancer effect
by the drug combinations via … An optimal protocol of combination therapy may improve the …

Dietary polyphenols: promising adjuvants for colorectal cancer therapies

L Bracci, A Fabbri, M Del Corno, L Conti - Cancers, 2021 - mdpi.com
optimalinduced, in a panel of human colon cancer cell lines with distinct mutations in the
KRAS, NRAS, BRAF, and PIK3CA genes, synergistic anti-proliferative and apoptotic effects via