… in MICA HCs increased the NKG2D–MICA interaction affinity … experience from antibody
affinity maturation. Antibodies bind … NKG2D binding interface residue was mutated in the MICA …

… ) combined with IL-18 (75 ng/ml) enhanced NKG2D expression … affinity of soluble MICA
and MICB for the NKG2D receptor than MULT1 [21], which may also explain why the shed MICA …

… similar to the reported affinity data of MICA to NKG2D [35]. … In this study, docetaxel combined
with JZC01 reduced tumor … , in our study the MICA fusion antibody JZC01 increased NKG2D-…

… cell:target cell interface and promote dephosphorylation of … Moreover, affinity matured
sequences of functional domains … ligands, such as ULBP2 for the NKG2D receptor or B7-H6 for the …

… of the NKG2D-mediated response to specific MICA variants … -NKG2D interface compared
to those in the ULBP3-NKG2D … However, rational interventions will require a more advanced …

… Still, a rational design of immunotherapies is only possible … synapse is formed at the interface
between the two cells. … microstrips of NKG2D antibodies and a mix of NKG2D antibody and …

… at the variable-constant interface was higher in comparison to … The ligands for NKG2D
include MICA, MICB, and ULBP1-6, … through interaction with another NKG2D ligand, Rae1 [79]. …

… and bind MICA/B and ULBPs through NKG2D, and the signal … Vγ9Vδ2 T cells in vivo or in
vitro combined with IL-2. In a phase I … In order to rationally utilize γδ T cells and their ligands for …

… provide the rational for developing different … NKG2D is the major responsible of CIK cell
MHC-unrestricted tumor killing activity by the recognition of MHC-class I-like molecules, MICA, …

… Induction of ADCC by therapeutic mAbs is substantially affected by antibody binding interfaces,
… In a separate study, the NKG2D ligand MHC class I-related chain A (MICA) was fused to …