… abbreviations UMOD for the human uromodulin gene; Umod … mutations driving UMOD-ADTKD
disease cause misfolding … the regulation of blood pressure and kidney function has vastly …

… studies have implicated genetic variants in UMOD, MYH9, … The common outcomes of
hypertensive renal disease are … genetic basis of salt-sensitive hypertension and renal injury by …

… have linked common UMOD variants with kidney function, … transport in the kidney and
salt-sensitive hypertension, such … of urinary UMOD levels on salt-induced blood pressure changes …

… in Mendelian diseases, to common variants, often non-coding … for variants associated with
salt-sensitive hypertension, ie, a … mutations in UMOD represent the most frequent cause of …

… Moreover, it was associated with salt–sensitive hypertension and kidney damage in mice …
the susceptibility to hypertension and kidney damage during midlife, UMOD risk variants may …

… new genetic variants associated with common diseases. … time predisposes to kidney damage
induced by additional … and it causes salt-sensitive hypertension and kidney damage in mice …

… events, such as stroke, heart and kidney failure [1]. Essential … ), salt-sensitive and non-salt-sensitive
hypertensive subjects … It was demonstrated that some gene variants in UMOD are …

… 4 common variants in the promoter region of the UMOD gene … both in vitro and in vivo,
which could cause over-activation of … to salt-sensitive hypertension and age-dependent kidney …

… from the original Baoji Salt-Sensitive Study cohort were … risk of cardiovascular disease
and all-cause mortality, is … the UMOD gene in this study, less frequent genetic variants may …

… than Umod +/+ mice, are resistant to salt-induced changes in … previously that Umod is
associated with salt-sensitive HTN, … essential HTN, antibodies to HSP70 are commonly observed …