… Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney
damage by increasing … Mutations of the UMOD gene are responsible for medullary cystic kidney …

… reported to develop hypertension, while UMOD-deficient … mRNA, tRNA, rRNA and noncoding
RNA, produced by an … in microbial composition between salt-sensitive and salt-resistant rats…

… in patients for whom the leading cause of disease was hypertension or diabetes, the most
… and salt-sensitive hypertensive CKD 31 . In support, the risk allele at the UMOD variant was …

… UMOD noncoding (regulatory) common variants have been consistently associated with kidney
function, CKD, and hypertension in … that UMOD plays a role in salt-sensitive hypertension …

… the UMOD gene encoding uromodulin as a cause of inherited kidney disease ( 6 ). Uromodulin
… in the human genome, with most SNPs occurring in noncoding regions. For instance, the …

… Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney
damage by increasing uromodulin expression. Nat Med . 2013;19(12):1655–1660. …

… Missense mutations in the UMOD gene cause autosomal … the UMOD gene are also associated
with kidney disease 9 . … of uromodulin in the kidney can lead to salt-sensitive HTN. The …

… common variants in the promoter region of the UMOD gene … to chronic kidney disease and
arterial hypertension (AH)2-5. … intake alter blood pressure (BP) in salt-sensitive individuals, …

… Common noncoding UMOD gene variants induce saltsensitive hypertension and kidney
damage by increasing uromodulin expression. Nature Medicine. 2013; 19 (12): 1655-1660. …

… tion of UMOD with blood pressure through effects on gene … expressed genes (138 protein
coding genes,18 long non-coding … Saltsensitive women are more likely to develop aggravated …