Emerging roles of RNA‐binding proteins in diabetes and their therapeutic potential in diabetic complications

CA Nutter… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
… are important for insulin sensitivity. LIN28 is strongly … HMGA2, which is a risk allele for T2D
(Table 1). IGF2BP2 is an important factor in pathogenesis of diabetic nephropathy (Table 2). It …

RNA-binding proteins and their role in kidney disease

L Seufert, T Benzing, M Ignarski… - Nature Reviews …, 2022 - nature.com
… tubule cells upregulated the short transcript variant of HuR in a Smad–BMP-dependent
manner 65 , whereas the long transcript variant was downregulated in response to decreased …

[引用][C] Diabetic Nephropathy: Proteinuria, Inflammation, and Fibrosis

L Gnudi

[PDF][PDF] WJD

C Muntean, IM Starcea, C Banescu, HQ Li, N Liu… - 2022 - researchgate.net
diabetic nephropathy pathogenesis in type 2 diabetic db/db … and to identify genes that confer
susceptibility to disease. … [29] identified 24 genetic variants in 16 genes (EPO, APOE, APOC1…

Pathoepigenetics: the role of epigenetic biomarkers in disease pathogenesis

R Cacabelos - Pharmacoepigenetics, 2019 - Elsevier
… hTERT expression and increased sensitivity to the induction of … variant as the major common
genetic determinant of NAFLD. … renal disease are common complications in patients with …

Variants in FSHB Are Associated With Polycystic Ovary Syndrome and Luteinizing Hormone Level in Han Chinese Women

Y Tian, H Zhao, H Chen, Y Peng, L Cui… - The Journal of …, 2016 - academic.oup.com
type 2 diabetes, and dyslipidemia, which are associated with long-term health (4–6). … two
new susceptibility loci identified in the European GWAS and assess the contributions of genetic

Long non-coding RNAs in metabolic disorders: pathogenetic relevance and potential biomarkers and therapeutic targets

B Alipoor, S Nikouei, F Rezaeinejad… - Journal of …, 2021 - Springer
Type 2 diabetes (T2D) is marked by insulin resistance—known … patients decreases sensitivity
to insulin through up-regulation of … Diabetic nephropathy (DN) is one of the most common

MicroRNA sequences modulated by beta cell lipid metabolism: Implications for type 2 diabetes mellitus

JMR Tarlton, S Patterson, A Graham - Biology, 2021 - mdpi.com
… lack of insulin sensitivity in hepatic and peripheral tissues [2], … diabetes in ‘prediabetic’
patients [77], and genetic variants in HMGCR have also been linked with predisposition to diabetes

The role of genetic polymorphisms in differentiated thyroid cancer: a 2023 update

RA Tiucă, OM Tiucă, IM Pașcanu - Biomedicines, 2023 - mdpi.com
… . that combined the results of 15 studies found that common variants of FOXE1 rs965513,
rs944289, and rs1867277 were risk factors for increased susceptibility to developing DTC [68]. …

MicroRNAs as regulators of metabolic disease: pathophysiologic significance and emerging role as biomarkers and therapeutics

JA Deiuliis - International journal of obesity, 2016 - nature.com
… in patients with T2DM, with a focus on diabetic nephropathy … process involving genetic and
epigenetic predisposition and … in patients with and without known genomic variants and the …