Nicardia® XL (Nifedipine Extended Release): Technologically Advanced GITS Formulation Ensures Robust Efficacy and Assured Safety

S Mavani, MA Abraham, A Conjeevaram… - Journal of Drug …, 2022 - jddtonline.info
… Nifedipine GITS is a gold standard once-daily formulation of … , Nicardipine, and Isradipine in
resistant hypertensive patients. … Nifedipine GITS or sustained-release Propranolol for 8 weeks…

L-type Ca2+ channel blockade with antihypertensive medication disrupts VTA synaptic plasticity and drug-associated contextual memory

M Degoulet, CE Stelly, KC Ahn, H Morikawa - Molecular Psychiatry, 2016 - nature.com
… Ca) at the time of induction was comparable to that observed in … Thus, we sought to determine
whether isradipine affects … repeated expression tests (posttests; once daily), where rats are …

Furazans in medicinal chemistry

RS Mancini, CJ Barden, DF Weaver… - Journal of Medicinal …, 2021 - ACS Publications
… ; for example, once daily controlled release or twice daily … Comparative studies between
isradipine (benzofurazan) and … study (MIDAS) concluded that isradipine is more efficacious than …

Direct vasodilators and sympatholytic agents

MN McComb, JY Chao, TMH Ng - Journal of cardiovascular …, 2016 - journals.sagepub.com
… However, when compared to nifedipine or isradipine, there … As a once-daily antihypertensive,
it has been shown to … approved Cardura XL, a sustained release form of doxazosin. …

Circadian variation in efficacy of medications

JC Walton, WH Walker, JR Bumgarner… - Clinical …, 2021 - Wiley Online Library
… , verapamil, diltiazem, and isradipine. For instance, nifedipine … morning administration for
treating hypertension; night-time … comparing a once-daily administration of sustained release

[PDF][PDF] Update on the drug treatment of hypertension: perspectives in clinical pharmacology

L Chuyen, NTL Nhi, NT Do Thi Hong Diep, NLHV Tin - jmp.huemed-univ.edu.vn
… be given in sustained-release forms. Bisoprolol and nebivolol have half-life values of 10 -
12 h that can be used once daily. Effecfiveness: the ideal β-blocker for hypertension is long …

Extent of asleep blood pressure reduction by hypertension medications is ingestion-time dependent: Systematic review and meta-analysis of published human trials

RC Hermida, A Mojon, RG Hermida-Ayala… - Sleep Medicine …, 2021 - Elsevier
review of published human trials regarding ingestion-time differences in the effects of
hypertension … and 2020, totaling 6120 hypertensive persons, evaluated 21 different single and 8 …

Considering circadian pattern of blood pressure in the treatment of hypertension via chronotherapy: a conducive or maladroit approach

R Das, DK Mehta - Current Drug Targets, 2019 - ingentaconnect.com
… treatment of hypertension comparing the once-daily (evening) … A sustained-release formulation
of diltiazem was found to be … Both isradipine treatment schedules were equally effective in …

Chronopharmacology: appraising the influence of biorhythms on the efficacy and safety of antihypertensive drugs

U Saleem, S Iman, MF Akhtar, A Saleem… - Critical Reviews™ in …, 2019 - dl.begellhouse.com
… amlodipine administration, sustained-release isradipine, … A four-week study of isradipine
in 16 secondary hypertensive … Doxazosin was administered once daily in the morning in the …

Oral controlled and sustained drug delivery systems: Concepts, advances, preclinical, and clinical status

G Kaur, J Grewal, K Jyoti, UK Jain, R Chandra… - Drug targeting and …, 2018 - Elsevier
… on basics of controlled and sustained release dosage forms, as … in dosage form design in
comparison to other routes. Moreover, … Thus, once daily dosage form maintains uniform plasma …