The differential in vivo contribution of spinal α2A- and α2C-adrenoceptors in tonic and acute evoked nociception in the rat
G López-Córdoba, G Martínez-Lorenzana… - Frontiers in …, 2022 - frontiersin.org
… antinociceptive effects in the formalin test, we tested the … The difference in neuronal activity
evoked within one group … of α 2 -adrenoceptor agonists (ST-91 or tizanidine given systemically…
evoked within one group … of α 2 -adrenoceptor agonists (ST-91 or tizanidine given systemically…
Spinal α2‐adrenoceptors and neuropathic pain modulation; therapeutic target
Z Bahari, GH Meftahi - British Journal of Pharmacology, 2019 - Wiley Online Library
… evidence has proved the antinociceptive role of spinal α-… , thereby causing analgesic effects
of α-adrenoceptor ligands. … pain received 1 to 4 mg of tizanidine once daily for 7 days; 68…
of α-adrenoceptor ligands. … pain received 1 to 4 mg of tizanidine once daily for 7 days; 68…
Dual μ-opioid receptor and norepinephrine reuptake mechanisms contribute to dezocine-and tapentadol-induced mechanical antiallodynia in cancer pain
… injection of the α-adrenoceptor antagonist phentolamine/α2-… of dezocine and tapentadol
by a head-to-head comparison … , suggesting that their antinociception is entirely medicated by …
by a head-to-head comparison … , suggesting that their antinociception is entirely medicated by …
Zerumbone modulates α2A-adrenergic, TRPV1, and NMDA NR2B receptors plasticity in CCI-induced neuropathic pain in vivo and LPS-induced SH-SY5Y …
… conducted using selective α-adrenoceptor antagonists; prazosin … Thus, the antinociceptive
activity due to α 2 -AR activation is … not significantly increase in comparison to naïve and sham …
activity due to α 2 -AR activation is … not significantly increase in comparison to naïve and sham …
Effects of fadolmidine, an α2‐adrenoceptor agonist, as an adjuvant to spinal bupivacaine on antinociception and motor function in rats and dogs
T Leino, T Viitamaa, JS Salonen… - Pharmacology …, 2021 - Wiley Online Library
… the duration of the antinociceptive effect when compared to either … agonist (eg clonidine,
tizanidine) and a local anesthetic is … It is suggested that α-adrenoceptor agonist responsiveness …
tizanidine) and a local anesthetic is … It is suggested that α-adrenoceptor agonist responsiveness …
Fadolmidine–Favourable adverse effects profile for spinal analgesia suggested by in vitro and in vivo models
T Leino, J Lehtimäki, A Koivisto, A Haapalinna… - European Journal of …, 2020 - Elsevier
… both α-adrenoceptor antagonists. When no antagonist was used, saline was injected to
compensate for the possible volume effect … comparisons, and the significance of the differences …
compensate for the possible volume effect … comparisons, and the significance of the differences …
[PDF][PDF] PREMATURE EJACULATION–POTENTIAL ROLE OF α2-ADRENOCEPTOR AGONISTS FOR SYMPTOMATIC TREATMENT
J Lehtimäki - utupub.fi
… activity ratio, was significantly higher in men with premature ejaculation compared to a …
) or a combination of both α-adrenoceptor antagonists. When no antagonist was employed, …
) or a combination of both α-adrenoceptor antagonists. When no antagonist was employed, …
Short onset and enhanced analgesia following nasal administration of non-controlled drugs in nanovesicular systems
… , the effect of the new nanocarrier on the antinociceptive effect of … system emphasizes the
important role of the phospholipid soft … in Phospholipid Magnesome in comparison with nasal …
important role of the phospholipid soft … in Phospholipid Magnesome in comparison with nasal …
Xylazine Adulteration of the Heroin–Fentanyl Drug Supply: A Narrative Review
J D'Orazio, L Nelson, J Perrone… - Annals of Internal …, 2023 - acpjournals.org
… actions (13, 14). In horses, combining opioids with xylazine resulted in an enhanced duration
of sedation and analgesia compared … did not require airway intervention, consistent with …
of sedation and analgesia compared … did not require airway intervention, consistent with …