Comparison of canine and human physiological factors: understanding interspecies differences that impact drug pharmacokinetics

MN Martinez, JP Mochel, S Neuhoff, D Pade - The AAPS journal, 2021 - Springer
… To appreciate the canine-human differences that can … a comparison of the physiology, drug
transporter/enzyme location, abundance, activity, and specificity between dogs and humans. …

Comparing dog and human intestinal fluids: implications on solubility and biopharmaceutical risk assessment

PL Walsh, J Stellabott, R Nofsinger, W Xu… - AAPS …, 2017 - Springer
… Despite many documented differences in gut physiology compared to humans, the beagle
dog … However, differences in pH and bile salt concentration and micellar structure between …

The canine gastrointestinal microbiota: early studies and research frontiers

Z Huang, Z Pan, R Yang, Y Bi, X Xiong - Gut Microbes, 2020 - Taylor & Francis
canine gut microbiota is similar to the human gut microbiota, and dietary factors affect both.
Studying canine intestinal … the canine GI microbiome revealed that differences in the levels of …

In vitro models of the canine digestive tract as an alternative to in vivo assays: Advances and current challenges

C Deschamps, S Denis, D Humbert… - ALTEX-Alternatives …, 2022 - refubium.fu-berlin.de
… digestion and gut microbiota as key factors in dog nutrition … similarities and differences
between the human and canine … key process in both dog and human gut physiology. To further …

Variation of the microbiota and metabolome along the canine gastrointestinal tract

JB Honneffer, JM Steiner, JA Lidbury, JS Suchodolski - Metabolomics, 2017 - Springer
gastrointestinal physiology, the goal of this study was to sample multiple sites along the
canine … ), treating each dog as a block and testing for significant differences with Kruskal–Wallis …

[HTML][HTML] A comparative assessment of the diagnosis of swallowing impairment and gastroesophageal reflux in canines and humans

TV Ullal, SL Marks, PC Belafsky, JL Conklin… - Frontiers in Veterinary …, 2022 - frontiersin.org
Similarities in anatomy and physiology between humans and canines results in analogous
… Accordingly, the diagnostic approach to human and canine patients with swallowing …

Canine and feline parasitology: Analogies, differences, and relevance for human health

S Morelli, A Diakou, A Di Cesare… - Clinical microbiology …, 2021 - Am Soc Microbiol
… based on different preys for dogs and cats, (ii) … similarities than differences in canine and
feline infections and associated diseases. Differences, similarities, and peculiarities of canine

[HTML][HTML] The role of the canine gut microbiome and metabolome in health and gastrointestinal disease

R Pilla, JS Suchodolski - Frontiers in veterinary science, 2020 - frontiersin.org
… meat-based raw diets in the gut microbiome of healthy dogs in comparison with kibble-fed …
, can have an impact on the gut microbiome. In a study comparing dogs and their owners, …

Comparison of healthy adult and puppy canine intestinal epithelium histological features

V Livania - 2022 - search.proquest.com
… pathophysiology of intestinal diseases that take place in humans. This … canines, because
canine gut physiology, diet, and intestinal microbiota are highly comparable to those of humans

Exploring Canine-Human Differences in Product Performance. Part II: Use of Modeling and Simulation to Explore the Impact of Formulation on Ciprofloxacin In Vivo …

MN Martinez, B Mistry, V Lukacova, KA Lentz, JE Polli… - The AAPS journal, 2017 - Springer
… Therefore, it is necessary to understand the interrelationship between drug physiochemical
characteristics, GI physiological attributes, and product formulation. Achieving this insight is …