CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG
Z Liu, X Zhang, H Lei, N Lam, S Carter… - Nature …, 2020 - nature.com
… By comparing CASZ1 and MYOD or MYOG ChIP-seq datasets … define genome wide
CASZ1-binding sites in a cellular differentiation system. We find that genes involved in a myogenic …
CASZ1-binding sites in a cellular differentiation system. We find that genes involved in a myogenic …
Twist2 amplification in rhabdomyosarcoma represses myogenesis and promotes oncogenesis by redirecting MyoD DNA binding
… dynamics in the context of differentiation, we performed genome-wide ChIP-seq for 3xTy1-Twist2
and MyoD in Tw2 … Comparison of our Twist2 and MyoD motifs reveals that both proteins …
and MyoD in Tw2 … Comparison of our Twist2 and MyoD motifs reveals that both proteins …
BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma
… in this malignancy compared to skeletal muscle and is essential for cell proliferation. …
genome-wide binding for PBRM1 and BRG1 in RH4 cells and analytically defined binding …
genome-wide binding for PBRM1 and BRG1 in RH4 cells and analytically defined binding …
Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma
… studies in human RMS uncovered that MYF5 and MYOD bind … MYF5 and MYOD are also
required for efficient human RMS … -strain transgenic fish and compared with those that express …
required for efficient human RMS … -strain transgenic fish and compared with those that express …
Actin-related protein 5 functions as a novel modulator of MyoD and MyoG in skeletal muscle and in rhabdomyosarcoma
T Morita, K Hayashi - Elife, 2022 - elifesciences.org
… Arp5 in myogenic differentiation of skeletal muscle cells. We … in Arp5- KO cells compared
with parental RD cells (Figure 7B)… a genome- wide ChIP- Seq analysis of MyoD using Arp5- KO …
with parental RD cells (Figure 7B)… a genome- wide ChIP- Seq analysis of MyoD using Arp5- KO …
Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma
S Pomella, P Sreenivas, BE Gryder, L Wang… - Nature …, 2021 - nature.com
… mapped the genome-wide profile of SNAI2 chromatin binding, … and MYOD average signals
compared to SNAI2 and MYOD … could be hindering MYOD from fully binding to key myogenic …
compared to SNAI2 and MYOD … could be hindering MYOD from fully binding to key myogenic …
Genomic and epigenetic changes drive aberrant skeletal muscle differentiation in rhabdomyosarcoma
S Pomella, SG Danielli, R Alaggio, WB Breunis… - Cancers, 2023 - mdpi.com
… describe differences in myogenic differentiation characteristics between different groups of
cells … While MYOD1 binds many genes in muscle cells, it modifies gene expression only at a …
cells … While MYOD1 binds many genes in muscle cells, it modifies gene expression only at a …
[HTML][HTML] SIX1 reprograms myogenic transcription factors to maintain the rhabdomyosarcoma undifferentiated state
JY Hsu, EP Danis, S Nance, JH O'Brien, AL Gustafson… - Cell reports, 2022 - cell.com
… of RMS differentiation via genome-wide alterations in MYOD1 and … Genome-wide MyoD
binding in skeletal muscle cells: a … comparison of the RMS cell lines against all other tumor cell …
binding in skeletal muscle cells: a … comparison of the RMS cell lines against all other tumor cell …
Biological Role and Clinical Implications of MYOD1L122R Mutation in Rhabdomyosarcoma
D Di Carlo, J Chisholm, A Kelsey, R Alaggio… - Cancers, 2023 - mdpi.com
… myoblasts, RMS typically expresses both MYOD1 and myogenin yet fails to undergo … to
bind myogenic loci more poorly in the RD embryonal RMS cell line compared to primary human …
bind myogenic loci more poorly in the RD embryonal RMS cell line compared to primary human …
Dysregulated myogenesis in rhabdomyosarcoma
YY Peter, DC Guttridge - Current Topics in Developmental Biology, 2018 - Elsevier
… In this review, we discuss recent genome-wide analyses that have … cells are impaired in
differentiation and MyoD and Myogenin … tumors that caused MyoD to preferentially bind to MYC …
differentiation and MyoD and Myogenin … tumors that caused MyoD to preferentially bind to MYC …