… is to gain a greater understanding of the molecular events during early human T-cell
differentiation to allow for dissection of particular genetic events that may occur in T-ALL. This was …

… A complementary DNA (cDNA) library was generated from 50 … regulation of hematopoietic
differentiation and self-renewal. … in the percentage of myeloid/B-lymphoid cells (Mac1 + Gr1 + …

… B lymphoid tyrosine kinase (Blk) knockout mice, which exhibit defective BCR signaling, have
increased numbers of splenic B-1a cells, which differentiate … proteins, complement pathway …

… We will also review the genetic and epigenetic alterations … B cell development and
differentiation and we will discuss how … through mutation of the complementarity determining …

Systemic sclerosis (SSc) is an orphan disease characterized by progressive fibrosis of the
skin and internal organs. Aside from vasculopathy and fibrotic processes, its pathogenesis …

… Gene Ontology analysis demonstrates that genes within 12 kb of lost PU.1 binding sites are
involved in immune cell activation and differentiation (Figure S1B). In contrast, PU.1 binding …

… during the pharmacologically induced differentiation of leukemic precursor B … differentiation
were determined and compared to those of established early B lymphoid differentiation …

… Alterations of both anti-apoptotic and pro-apoptotic genes through genetic or epigenetic
mechanisms have been observed in cancer. a | Increased levels of anti-apoptotic BCL-2 family …

… common activation of an early myeloid programme. Moreover… mechanism to prevent precocious
B‐lymphoid differentiation, … complementary roles in suppressing myeloid differentiation. …