… use of IVIg, a comprehensive clinical guideline for the use of IVIg in … The pathogenic relevance
of FcRn in autoimmune bullous … The skin is usually affected in a UV-dependent fashion. …

… In autoimmune bullous diseases, IVIGs can be used in an … explained by an exclusively
FcRn-dependent mechanism. Finally, it … The full text of this article hosted at iucr.org is unavailable …

… , and various skin blistering diseases severely impacts quality of … both FcRn and the family
of canonical FcγRs are central to IgG (… on how IVIg may modulate IgG-dependent autoimmune …

… FcRn mAb which determined sustained dose-dependent … procedure applied to remove
total IgG from patient plasma using … Intravenous immunoglobulin (IVIG) treatment is utilized to …

… As such, in addition to liver synthesis, pH-dependent FcRn … Treatment with intravenous
immunoglobulin (IVIg) may further … in FcRn inhibitor design, such as format (full-length IgG vs Fc …

… Our current understanding of IVIg is dependent on the underlying disease process, and the
… FcRn appears to have an important role in autoimmune bullous disease as FcRn deficient …

… achieved complete remission on therapy within 2 months and … diminish blister formation in
a dose-dependent fashion.103, 105 … In the circulation, FcRn protects circulating IgG antibodies …

… trials are completed, the information that IVIg preparations contain … of IgG derived from IVIg
administrations saturate the FcRn so … IVIg causes a dose-dependent downregulation on their …

… are mostly dependent on the constant Fc portion of the IgG … tracer IgG is significantly enhanced
by blockade of FcRn with … ), MG and skin blistering diseases have been communicated on …

… in multiple autoimmune diseases, reducing total IgG could … randomised 1:1 to efgartigimod
IV 10 mg/kg or placebo. A … In our study, an IgG response to T-cell dependent vaccines was …