… Full size image The cutaneous symptoms with tense blistering suggested an autoimmune
bullous disease, … Thus, we speculated that the IgG4 of anti-BP180 antibody bound to FcRn was …

… Maintenance of serum IgG levels is proportionally more dependent on … autoimmune diseases,
which may reduce pressure for Ig on … Novel therapies such as FcRn inhibitors may reduce …

… This review focuses on the role of FcRn in autoimmunity, … of autoreactive IgG by blocking
FcRn-dependent recycling. … represented category is FcRn-specific, full IgG formats. These …

… potentially lethal mucocutaneous blistering disease characterized by IgG autoantibodies (…
Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases…

… been proposed/explored for managing autoimmune bullous diseases. These hold potential
for … of various biologics in the treatment of autoimmune bullous diseases, followed by a brief …

… (PV) is an autoimmune skin blistering disease caused by anti-… decreased by IVIG treatment
in a dose-dependent manner, … and mouse FcRn share high homology and human IgG can …

… also be inhibited by IVIg through a Fc-dependent mechanism. … , autoimmune myasthenia
gravis, skin blistering diseases … that IVIg therapy in FNAIT competitively occupies the FcRn sites …

… Antibody therapies targeting FcRn, testing those anti-FcRn … IgG subclass, comprising less
than 5% of the total IgG with … phagocytosis or antibody-dependent cellular cytotoxicity; because …

… -dependent antigen also led to lower antigen-specific IgG titers… neonatal Fc receptor (FcRn)
(43). By administering excess … and healthy skin in experimental pemphigoid disease, several …

… Fc-dependent activities (ie, blockade of the neonatal FcRn and … FcRn is a transport receptor
that binds intracellular IgG and … of IVIG treatment (resulting in 2 g and 2.4 g total IVIG doses, …