… animal models and the investigation of the genetics of rare and common human forms of
obesity… that meta-analyses of genetic studies for obesity can be difficult to evaluate due to the …

… Obesity and its related disorders are complex quantitative … Mutating these single genes in
a mouse model can provide some … QTLs associated with genetic obesity in 129S and B6 mice …

… animal models are valuable; unique genetic tools in the mouse make it a particularly useful
animal model. … potentially obscuring our understanding of complex diseases. To determine …

… Gene–gene interactions are difficult to identify using traditional genetic studies in humans …
increased risk for genetic obesity, and this may influence choices or approaches to treatment. …

… Both obesity and diabetes are complex diseases that involve the interaction of … genetic
and environmental factors. Genetically-modified animal models that reflect human obesity …

… how appropriate animal models can help dissect the complex interaction of host genetics
with … To begin to define the role of the microbiome in gene/environment interaction in obesity, …

… of mouse models that consistently develop all of these features has proven difficult. Instead,
… One of the best known genetic models is the non-obese diabetic (NOD) mouse, which …

… complex interactions between genetic factors, sex, obesity … obesity and flavonoid response
mechanisms. In summary, while the diet-induced obesity C57BL/6 J male mouse model is …

… of human obesity and is extremely flexible to use in combination with any molecular
genetic … In contrast, monogenetic mouse models are often difficult to breed and observed …

… obesity during pregnancy and its effects on offspring, with a focus on female subjects. Animal
model … The inheritance of obesity is influenced by a complex interplay of genetic, epigenetic…