… This article describes the works done on enzyme models and the computational … of Kirby’s
enzyme models were used to design simvastatin prodrugs (Figure 7) by linking the statin-free …

… is devoted to cover reported studies on enzyme models and … anti-malarial atovaquone, and
statins for lowering cholesterol … we have computationally studied the hydrolysis of Kirby’s N-…

… statins, or substitute for patients who are intolerant to statins, … In the era of advanced
technology, various computational … on proton transfers in Kirby’s enzyme model by linking the free …

… were investigating the effects of statins in combination or as … gained without the use of
computational data. However, to … Bruice’s cyclization of dicarboxylic semiesters and Kirby’s acid-…

… enzyme models were utilized in my prodrug design approach which was accomplished using
computational calculations based … [73, 79, 80] and statins for treatment of high cholesterol …

… and kinetic studies described in this paper is based on intramolecular process using molecular
… Computationally designed prodrugs of statins based on Kirby’s enzyme model. Journal of …

… Analyzing the efficiency of proton transfer to carbon in Kirby’s enzyme model: A computational
… Computationally designed prodrugs of statins based on Kirby's enzyme model. J Mol …

… ester-based prodrugs for activation (hydrolysis) of prodrugs to … For this purpose, we have
computationally researched the … prodrugs to treat myelodysplastic syndromes [89] and statins …

… (BPD), which was synthesized as a model prodrug due to its amphiphilic … Gene-directed
enzyme prodrug therapy (GDEPT) is … The computational approaches for prodrug design have a …

… However, the model continued to under-predict the statin … is SN-38, the active anti-cancer
metabolite of the prodrug … in transporters and metabolizing enzymes is a significant limitation …