Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications
T Chujo, K Tomizawa - The FEBS journal, 2021 - Wiley Online Library
… However, every anticodon loop entering the ribosomal A-site must have a similar conformation
to … To the best of our knowledge, this is the first case of detailed (although not complete) …
to … To the best of our knowledge, this is the first case of detailed (although not complete) …
[HTML][HTML] Transfer RNA modification and infection–implications for pathogenicity and host responses
C San Koh, LP Sarin - Biochimica et Biophysica Acta (BBA)-Gene …, 2018 - Elsevier
… ) can influence the sugar conformation in nucleic acids [40]. … ′-endo conformation are
preferentially incorporated by RNA … how tRNA modifications are able to expand the initial coding …
preferentially incorporated by RNA … how tRNA modifications are able to expand the initial coding …
Transfer RNA-derived fragments and tRNA halves: biogenesis, biological functions and their roles in diseases
Y Shen, X Yu, L Zhu, T Li, Z Yan, J Guo - Journal of Molecular Medicine, 2018 - Springer
… damage has attracted attention. Oxidative stress may induce changes in tRNA conformations
… In conclusion, studies on tRFs and tRNA halves are still in a very early stage. Because of …
… In conclusion, studies on tRFs and tRNA halves are still in a very early stage. Because of …
Recent advances: molecular mechanism of RNA oxidation and its role in various diseases
Z Li, X Chen, Z Liu, W Ye, L Li, L Qian… - Frontiers in Molecular …, 2020 - frontiersin.org
… the relationship between the RNA damage and disease as … prevent its function or change
the conformation of the target … suggest that RNA oxidation may occur in the early stage of PD…
the conformation of the target … suggest that RNA oxidation may occur in the early stage of PD…
Cellular origins of dsRNA, their recognition and consequences
YG Chen, S Hur - Nature Reviews Molecular Cell Biology, 2022 - nature.com
… We first discuss the dsRNA sensors in the vertebrate innate immune system, with the focus
on their signalling pathways, mechanisms and RNA … an active site conformational change to …
on their signalling pathways, mechanisms and RNA … an active site conformational change to …
Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center
J Willi, P Küpfer, D Evéquoz, G Fernandez… - Nucleic acids …, 2018 - academic.oup.com
… every codon with its cognate transfer RNA (tRNA) that carries a … To measure tRNA binding
to the A-site, the P-site was first … also lead to a shift from the anti to the syn conformation in the …
to the A-site, the P-site was first … also lead to a shift from the anti to the syn conformation in the …
Optimized photochemistry enables efficient analysis of dynamic RNA structuromes and interactomes in genetic and infectious diseases
… the first whole genome structure of enterovirus D68, an RNA … To prevent, repair or bypass
UVC-induced RNA damages, we … can induce minor conformations changes in IRES structures …
UVC-induced RNA damages, we … can induce minor conformations changes in IRES structures …
tRNA fragmentation and protein translation dynamics in the course of kidney injury
I Mami, N Pallet - RNA biology, 2018 - Taylor & Francis
… To monitor tRNA conformational changes under cellular stress, as a marker of tRNA … is
reasonable if we consider that tRNA fragmentation is an early stress-response event that could …
reasonable if we consider that tRNA fragmentation is an early stress-response event that could …
ADP-ribosylation of RNA and DNA: from in vitro characterization to in vivo function
L Weixler, K Schäringer, J Momoh… - Nucleic acids …, 2021 - academic.oup.com
… In this Survey and Summary, we first provide an overview of the transferases performing this
… a conformational change of the whole multi-domain folding upon interaction with damaged …
… a conformational change of the whole multi-domain folding upon interaction with damaged …
RNA modifications: importance in immune cell biology and related diseases
L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
… However, some modifications are further modified by enzymes, which we term for the first
time as “modifiers”. The modifications are identified by RNA-binding proteins (RBP) known as “…
time as “modifiers”. The modifications are identified by RNA-binding proteins (RBP) known as “…