… and molecular mimicry between foreign and self-peptides could … find that the non-disease-associated
subtype HLA-B2709, … of peptide residues that exhibit conformational dimorphism. A …

… distinct conformations by the disease-associated subtype B*… conformation, suggesting
the existence of “molecular mimicry” … MHC class I proteins in complex with viral and self-peptides. …

… dimorphism (Fig. 1D). … the structurally similar and unusual conformation observed of both
pVIPR and … due to molecular mimicry. The crystallographic structure contained two distinct …

… dimorphism (Figure 1D). … the structurally similar and unusual conformation observed of both
pVIPR and … due to molecular mimicry. The crystallographic structure contained two distinct …

… at presenting self-peptides that cross-react with pathogen-derived peptides (“molecular
mimicry”… multiple peptide-binding conformations and enhanced molecular flexibility that modulate …

… Next, we asked whether the relative expression of HLA-B*2705 and HLA-B*2709 molecules
… for the conformational HLA-B27 forms (also recognizing the HLA-B7 molecules, however, …

… They are also found to be directed against self-peptides derived from … The molecular mimicry
between HLA-B27 and gram-… Research revealed the presence of disease associated SNPs …

… However, the abovementioned conformational rules can be used to design efficient
sampling strategies for the docking of peptides in the binding groove of an MHC molecule. …

… acids when the enzyme is in a closed conformation. The disease-protective arginine substitution
at … IL-23 signaling is then potentiated by disease-associated variants in IL-23 signaling …

… Upon encountering a suboptimally loaded MHC I molecule, Tsn shifts the conformational
equilibrium to an open conformation of the binding groove by interacting with the α 2-1 helix, …