Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis

T Sommermann, T Yasuda, J Ronen… - Proceedings of the …, 2020 - National Acad Sciences
… (EBF1) to promote transformation of LMP1-expressing B cells by … EBV EBNA3A phenocopies
EBF1 activities in LMP1-… LMP1 constitutively activates the IKK signaling cascade, while Rel …

[HTML][HTML] Contribution of EpsteinBarr virus latent proteins to the pathogenesis of classical hodgkin lymphoma

K Vrzalikova, T Sunmonu, G Reynolds, P Murray - Pathogens, 2018 - mdpi.com
… and LMP1 have been shown to be essential for the in-vitro … , which, when depleted, partially
phenocopied EBNA1 depletion by … LMP1 has many functional similarities to a constitutively

Epstein-Barr virus infection phenocopies apoptosis regulation in germinal center B cells

J Dai - 2019 - search.proquest.com
… of immortalization and growth-transformation of B cells infected in vitro. The work … LMP1
and LMP2A are viral homologues of CD40 and BCR, respectively. LMP1 signals constitutively

Critical review of EpsteinBarr virus microRNAs relation with EBV‐associated gastric cancer

A Zebardast, SS Tehrani, T Latifi… - Journal of cellular …, 2021 - Wiley Online Library
… The LMP1 is a main oncogene encoded by EBV that initiates … miR-BART target mRNAs to
phenocopy their antiapoptotic effect in … validation in both in vitro and in vivo. The advantages of …

Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus

J Dai, ED SoRelle, E Heckenberg, L Song, JM Cable… - Mbio, 2024 - Am Soc Microbiol
constitutively through NF-κB and is required for proliferation … with delayed upregulation of
LMP1/NF-κB signaling in LCLs, … that an in vitro EBV infection of B cells phenocopies several …

[HTML][HTML] Epstein-Barr virus perpetuates B cell germinal center dynamics and generation of autoimmune-associated phenotypes in vitro

ED SoRelle, NM Reinoso-Vizcaino, GQ Horn… - Frontiers in …, 2022 - frontiersin.org
… The ability of EBV infection to phenocopy elements of the … LMP1, which mediates CD40
signaling, and LMP2A, which downregulates MHC class II expression and mimics a constitutively

[HTML][HTML] TRAF3 can interact with GMEB1 and modulate its anti-apoptotic function

G Kotsaris, D Kerselidou, D Koutsoubaris… - Journal of Biological …, 2020 - Springer
… inhibit the function of TRAF3 lead to constitutively active NF-… LMP1 is an oncoprotein expressed
by the Epstein Barr virus (… mammalian cells, using in vitro co-immunoprecipitation assays…

Epstein-Barr virus promotes survival through germinal center light zone chromatin architecture

J Dai, E Heckenberg, L Song, GE Crawford, MA Luftig - bioRxiv, 2020 - biorxiv.org
… , LMP1 expression in LCLs leads to constitutive activation of … with delayed upregulation of
LMP1/NFκB signaling in LCLs, … that an in vitro EBV infection of B cells phenocopies several …

[HTML][HTML] CRISPR/Cas9 screens reveal multiple layers of B cell CD40 regulation

C Jiang, SJ Trudeau, TC Cheong, R Guo, M Teng… - Cell reports, 2019 - cell.com
CD40 has major roles in B cell development, activation, and germinal center responses.
CD40 … arthritis guides a high-throughput drug screen of the CD40 signaling pathway. …

[HTML][HTML] EpsteinBarr Virus susceptibility in activated PI3Kδ syndrome (APDS) immunodeficiency

JM Carpier, CL Lucas - Frontiers in immunology, 2018 - frontiersin.org
… Another more recent phenocopy of APDS has been called … This constitutive complex remains
stable due to tight binding … LMP1 in particular is sufficient to transform several cell types, …