… , Gupta and colleagues in the Fisher laboratory constructed … not disrupt the tumor inhibitory
effects of MDA-7/IL-24. Interestingly, … Overexpression of mda-7/IL-24 by an adenoviral system …

… gene expression, attachment of secreted MDA-7/IL-24 to … The contribution of autophagy in
mda7/IL-24 tumor inhibitory … ), a transcription enhancer which is encoded by HIV virus. The …

… -defective adenovirus cannot target tumor cells, which limits its … activity inhibition, thereby
maintaining GSK-3β in its active form … Collectively, we constructed a recombinant vaccinia virus …

… , we constructed a human mda-7/IL24-encoding lentivirus, … Nonetheless, confirming a potential
role of MDA-7/IL-24 for … Our mechanistic studies using a pharmacologic inhibitor of STAT3 …

… plasmid encoding HPV-16 E7 (DNA vaccine) or the plasmid … usage [1], construction of
recombinant DNA vaccines [25], and … as a potent cytokine in inhibiting tumor growth and triggering …

… , the exogenous expression of IL-24 inhibited the growth of … The mda-7/IL-24 mRNA is 1718
base pairs long and encodes a … By constructing a non-secreted expression vector of IL-24 (…

… of a replication incompetent adenovirus expressing mda-7 (INGN … that MDA-7/IL-24-induced
IFN-γ upregulated PD-L1 expression in … on secondary structure of the encoded protein (46). …

… To overcome this limitation, we constructed a PEG/Lipids/… The three recombinant adenoviruses
(ZD55, ZD55-EGFP, … IL-24 also induced robust tumor inhibition (Fig. 1B) and greatly …

… Mda-7) encodes IL-24, … expression of Mda-7/IL-24, but its consequence depends on the cell
type by unknown mechanisms. The contribution of autophagy in Mda-7/IL-24 tumor inhibitory …

… the pRLTK luc construct encoding Renilla luciferase control. … to verify the inhibition of
proliferation by mda-7/IL-24 (bottom)… -221 following adenoviral-mediated delivery of mda-7/IL-24. …