The role of astrocytes in CNS inflammation

F Giovannoni, FJ Quintana - Trends in immunology, 2020 - cell.com
… been suggested to play a role in the control of astrocyte diversity in the homeostatic CNS [ …
NF-κB activation and worsened experimental autoimmune encephalomyelitis (EAE) (a model …

The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis

R Brambilla - Acta neuropathologica, 2019 - Springer
… diseases and the main functional roles of astrocytes in CNS physiology, we will delve into the
… [154], gene expression profiling of astrocytes isolated from EAE-induced and control mice …

[HTML][HTML] Environmental control of astrocyte pathogenic activities in CNS inflammation

MA Wheeler, M Jaronen, R Covacu, SEJ Zandee… - Cell, 2019 - cell.com
CNS inflammation in experimental autoimmune encephalomyelitis (EAE) and, potentially,
MS. In summary, these studies define environmental mechanisms that control astrocyte

Astrocytes: key regulators of neuroinflammation

E Colombo, C Farina - Trends in immunology, 2016 - cell.com
… They also play a role in the control of immune cell trafficking and activation. … Experimental
autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by …

[HTML][HTML] Astrocyte crosstalk in CNS inflammation

M Linnerbauer, MA Wheeler, FJ Quintana - Neuron, 2020 - cell.com
… of astrocyte heterogeneity and its control by astrocyte interactions with other cells in the central
nervous system (CNS)… roles of astrocytes in the context of CNS inflammation, highlighting …

Astrocyte tissue factor controls CNS hemostasis and autoimmune inflammation

S Wang, B Reeves, R Pawlinski - Thrombosis research, 2016 - Elsevier
… Both TF and PARs are widely expressed within the CNS, with TF expressed predominantly
by astrocytes and PARs expressed in multiple cell types including astrocytes, neurons, …

[HTML][HTML] PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation

M Linnerbauer, T Beyer, L Nirschl, D Farrenkopf… - Nature …, 2023 - nature.com
… To evaluate whether the expression of PD-1 by microglia is functionally relevant in the context
of CNS inflammation, we inactivated Pdcd1 under control of the Itgam1 (Cd11b) promoter …

Environmental control of autoimmune inflammation in the central nervous system

V Rothhammer, FJ Quintana - Current opinion in immunology, 2016 - Elsevier
… These AHR agonists dampen autoimmune inflammation in the CNS via AHR in astrocytes. …
Metabolites of dietary tryptophan control autoimmune inflammation in the CNS. The essential …

[HTML][HTML] Astrocyte-derived pleiotrophin mitigates late-stage autoimmune CNS inflammation

M Linnerbauer, L Lößlein, D Farrenkopf… - Frontiers in …, 2022 - frontiersin.org
astrocytes derived from 20 patients with MS and 28 control individuals demonstrated upregulation
of PTN in multiple subclusters of MS patients compared to controls (Figure … to controls, …

Microglial control of astrocytes in response to microbial metabolites

V Rothhammer, DM Borucki, EC Tjon, MC Takenaka… - Nature, 2018 - nature.com
… pro-inflammatory and neurotoxic activities in astrocytes, but the … of astrocytes in the
experimental autoimmune encephalomyelitis (… AHR in the control of CNS inflammation by dietary …