Applications of radiocomplexes with thiosemicarbazones and bis (thiosemicarbazones) in diagnostic and therapeutic nuclear medicine

GL Parrilha, RG dos Santos, H Beraldo - Coordination Chemistry Reviews, 2022 - Elsevier
… the first review that encompasses exclusively complexes with … tracers for cerebral and
myocardial blood flow was carried … lowers the Cu 2+ /Cu 1+ redox potential by around 60 mV/alkyl …

Patient-Derived Blood-Brain Barrier Model for Screening Copper Bis (thiosemicarbazone) Complexes as Potential Therapeutics in Alzheimer's Disease

JM Wasielewska, K Szostak, LE McInnes… - ACS chemical …, 2024 - ACS Publications
Cu levels were unlikely to confound our assessment of Cu … to the biologically inert
fluorescent tracer (5 kDa FITC-… identified opposite effects of Cu II (atsm) and Cu II (gtsm) on P…

Modification of biodistribution and brain uptake of copper bis (thiosemicarbazonato) complexes by the incorporation of amine and polyamine functional groups

BM Paterson, C Cullinane, PJ Crouch… - Inorganic …, 2019 - ACS Publications
… We have prepared a series of new bis(thiosemicarbazones) … of the Cu(btsc) complexes
strongly correlate with the Cu II/I … The new tracer, [ 64 Cu]Cu(L 2 ), was compared with [ 64 Cu]Cu(…

Copper bis (thiosemicarbazonato)-stilbenyl complexes that bind to amyloid-β plaques

A Noor, DJ Hayne, SC Lim, JK Van Zuylekom… - Inorganic …, 2020 - ACS Publications
… of the ligand have lower Cu II/I reduction potential and are therefore less … Both the tracers
show good brain uptake after 2 min … In this work a family of bis(thiosemicarbazone) ligands with …

A Copper Complex of a Thiosemicarbazone-Pyridylhydrazone Ligand Containing a Vinylpyridine Functional Group as a Potential Imaging Agent for Amyloid-β …

LE McInnes, A Noor, PD Roselt… - Australian Journal of …, 2019 - CSIRO Publishing
… for measuring altered copper trafficking in the brain during … weight of the tracer. To that
end we have investigated hybrid … The complex crystallises with the Cu II in a distorted square …

Copper complexes with dissymmetrically substituted bis (thiosemicarbazone) ligands as a basis for PET radiopharmaceuticals: control of redox potential and …

OC Brown, JB Torres, KB Holt, PJ Blower… - Dalton Transactions, 2017 - pubs.rsc.org
tracers for PET (positron emission tomography) for imaging hypoxic tissues, 1–4 cerebral 5
and myocardial perfusion, 6–9 changes in brain … 64 Cu or 62 Cu), has been widely evaluated

The pharmacological profile of metal complexes with bis (thiosemicarbazones) and bis (hydrazone)-derived ligands

AR Aguirre, H Beraldo - Polyhedron, 2024 - Elsevier
… showed less negative copper II/I redox potentials, and strong … uptake, being a potential
amyloid tracer for imaging of AD [8]. … -gp at the BBB to impact brain drug delivery and clearance of …

[PDF][PDF] Copper-64 radiopharmaceuticals for PET imaging of copper trafficking in neurological disorders

JB Torres - 2017 - kclpure.kcl.ac.uk
… of copper bis(thiosemicarbazone) complexes for potential use in … -injection of the tracer for
texture analysis; (B) 3D brain ROI; (C) … This article will then review the current uses of copper

In vivo quantitative whole-body perfusion imaging using radiolabeled copper (II) bis (thiosemicarbazone) complexes and positron emission tomography (PET)

MA Green, CJ Mathias, NJ Smith, M Cheng… - … Technologies: Volume 1, 2022 - Springer
… , a simple tracer kinetic model for estimation of perfusion using image-derived input
functions, and validation of the method against a reference standard perfusion tracer. A detailed …

Effect of structural modifications to glyoxal-bis (thiosemicarbazonato) copper (II) complexes on cellular copper uptake, copper-mediated ATP7A trafficking, and P …

KM Acevedo, DJ Hayne, LE McInnes… - Journal of medicinal …, 2018 - ACS Publications
… that [ 64 Cu]Cu(gtspyr) has reasonable brain uptake but high … copper(II) complexes of
bis(thiosemicarbazone) ligands (Cu(… the perfusion tracer 64 Cu(ptsm) and the hypoxia tracer 64 …